Reactions 1406 - 16 Jun 2012

SAntineoplastics

Colonic perforation and partial small bowelobstruction: case report

A 48-year-old man with primary effusion lymphoma(PEL) developed a colonic perforation, followed by a partialsmall bowel obstruction, while receiving antineoplastics.

The man, who had recently been diagnosed with HIV/AIDS and primary syphilis, was diagnosed withextracavitary PEL involving the colon. He subsequentlyreceived EPOCH chemotherapy, consisting of etoposide,vincristine [Oncovin], doxorubicin, cyclophosphamide andprednisone [dosages and routes not stated]. On day 7 oftherapy, he developed vague epigastric discomfort.Radiography findings were suggestive of a bowelperforation. Exploratory laparotomy showed a perforatedcaecum, splenic flexure of the colon and focal stomachnecrosis. The man underwent subtotal colectomy andpartial gastrectomy. His postoperative course requiredprolonged hospitalisation, with growth factor, blood,antibiotic and ventilatory support. After his eventualrecovery, he was discharged to a rehabilitation facility.

The man later received a further three cycles of EPOCHchemotherapy. During his last cycle, he developed a partialsmall bowel obstruction, for which he receivedconservative treatment. At last follow-up there was noradiographic evidence of disease.El-Ayass W, et al. Complete response to EPOCH in a patient with HIV andextracavitary primary effusion lymphoma involving the colon: A case report andreview of literature. Clinical lymphoma, myeloma and leukemia 12: 144-147, No.2, Apr 2012. Available from: URL: http://dx.doi.org/10.1016/j.clml.2011.12.003 -USA 803072215

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Reactions 16 Jun 2012 No. 14060114-9954/10/1406-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved