Oxcarbazepine
1
Reactions 1423 - 13 Oct 2012 S Oxcarbazepine Hypogammaglobulinaemia in a child: case report A 6-year-old girl developed hypogammaglobulinaemia during treatment with oxcarbazepine for epilepsy. The girl received oxcarbazepine [dosage and route not stated] starting in December 2008. In July 2009, she was hospitalised with septic shock secondary to Haemophilus influenzae pneumonia. During hospitalisation, laboratory tests revealed a low IgG level of 356 mg/dL and diminished B-cell count, as measured by CD19 lymphocytes, of 38 cells/mm 3 . IgA and IgM levels were normal. A diagnosis of oxcarbazepine-induced common variable immunodeficiency was proposed. Oxcarbazepine was discontinued and IV immunoglobulin therapy was initiated. Post-therapy the girl’s IgG level was elevated to 1041 mg/dL. After 2 months of treatment, her IgG level was 834 mg/dL. After 3 months, her hypogammaglobulinaemia had resolved and both her IgG level and B-cell count had normalised. Marinovic MA, et al. Case report: Hypogammaglobulinemia induced by oxcarbazepine. World Allergy Organization Journal 5 (Suppl. 2): S209 abstr. 606, Feb 2012. Available from: URL: http:// dx.doi.org/10.1097/01.WOX.0000411744.29602.2e - Chile 803078223 1 Reactions 13 Oct 2012 No. 1423 0114-9954/10/1423-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Oxcarbazepine
Reactions 1423 - 13 Oct 2012
SOxcarbazepine
Hypogammaglobulinaemia in a child: case reportA 6-year-old girl developed hypogammaglobulinaemia
during treatment with oxcarbazepine for epilepsy.The girl received oxcarbazepine [dosage and route not
stated] starting in December 2008. In July 2009, she washospitalised with septic shock secondary to Haemophilusinfluenzae pneumonia. During hospitalisation, laboratorytests revealed a low IgG level of 356 mg/dL and diminishedB-cell count, as measured by CD19 lymphocytes, of38 cells/mm3. IgA and IgM levels were normal. A diagnosisof oxcarbazepine-induced common variableimmunodeficiency was proposed.
Oxcarbazepine was discontinued and IVimmunoglobulin therapy was initiated. Post-therapy thegirl’s IgG level was elevated to 1041 mg/dL. After 2 monthsof treatment, her IgG level was 834 mg/dL. After 3 months,her hypogammaglobulinaemia had resolved and both herIgG level and B-cell count had normalised.Marinovic MA, et al. Case report: Hypogammaglobulinemia induced byoxcarbazepine. World Allergy Organization Journal 5 (Suppl. 2): S209 abstr. 606,Feb 2012. Available from: URL: http://dx.doi.org/10.1097/01.WOX.0000411744.29602.2e - Chile 803078223
1
Reactions 13 Oct 2012 No. 14230114-9954/10/1423-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
