Oxcarbazepine
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Reactions 1348 - 23 Apr 2011 S Oxcarbazepine Seizure worsening: case report A 19-year-old woman with Jeavons syndrome developed oxcarbazepine-induced worsening of seizures. The woman, who had a history of seizures presented with a 1-year history of worsened seizures. She had a generalised tonic-clonic seizure every month. A few seconds before the events, she developed eyelid flutter followed by myoclonic jerks involving her upper limbs. The worsening of her seizures coincided with the initiation of oxcarbazepine 20 mg/kg [frequency, indication and route not stated]. Evaluation revealed inter-ictal generalised fast polyspikes during wakefulness and sleep. She had one episode of prolonged eyelid myoclonic status, which progressed to multifocal myoclonic jerks and generalised tonic-clonic seizure. EEG in bright light, showed discharges occurring consistently after closing the eyes, but not in darkness. A diagnosis of Jeavons syndrome worsened by oxcarbazepine was made. Oxcarbazepine was tapered and the woman started receiving levetiracetam. EEG showed reduced interictal discharges. At 4-month follow-up, she reported one episode of brief absence with eyelid myoclonia on awakening. Menon R, et al. Oxcarbazepine induced worsening of seizures in Jeavons syndrome: Lessons learnt from an interesting presentation. Neurology India 59: 70-72, No. 1, Feb 2011. Available from: URL: http:// dx.doi.org/10.4103/0028-3886.76867 - India 803053137 1 Reactions 23 Apr 2011 No. 1348 0114-9954/10/1348-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Oxcarbazepine
Reactions 1348 - 23 Apr 2011
SOxcarbazepine
Seizure worsening: case reportA 19-year-old woman with Jeavons syndrome developed
oxcarbazepine-induced worsening of seizures.The woman, who had a history of seizures presented
with a 1-year history of worsened seizures. She had ageneralised tonic-clonic seizure every month. A fewseconds before the events, she developed eyelid flutterfollowed by myoclonic jerks involving her upper limbs. Theworsening of her seizures coincided with the initiation ofoxcarbazepine 20 mg/kg [frequency, indication and routenot stated]. Evaluation revealed inter-ictal generalised fastpolyspikes during wakefulness and sleep. She had oneepisode of prolonged eyelid myoclonic status, whichprogressed to multifocal myoclonic jerks and generalisedtonic-clonic seizure. EEG in bright light, showed dischargesoccurring consistently after closing the eyes, but not indarkness. A diagnosis of Jeavons syndrome worsened byoxcarbazepine was made.
Oxcarbazepine was tapered and the woman startedreceiving levetiracetam. EEG showed reduced interictaldischarges. At 4-month follow-up, she reported oneepisode of brief absence with eyelid myoclonia onawakening.Menon R, et al. Oxcarbazepine induced worsening of seizures in Jeavonssyndrome: Lessons learnt from an interesting presentation. Neurology India 59:70-72, No. 1, Feb 2011. Available from: URL: http://dx.doi.org/10.4103/0028-3886.76867 - India 803053137
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Reactions 23 Apr 2011 No. 13480114-9954/10/1348-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
