Lorazepam
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Reactions 1510, p29 - 19 Jul 2014 S Lorazepam Worsening of agitation treated with citalopram: case report An 84-year-old woman developed worsening of agitation during treatment with lorazepam and was eventually treated with citalopram. The woman who was acutely hospitalised due to physical aggression and somatic delusion, received lorazepam [route and dosage not stated]. She had also received risperidone, haloperidol and quetiapine. Later, it was found that lorazepam worsened the agitation [duration of treatment to reaction onset not stated]. The woman was treated with citalopram 10mg twice daily on admission, later increased to 15mg twice daily and within 72 hours, the agitation decreased dramatically. She was discharged soon. Later, on a follow-up, she was found in good behavioural control. Author comment: "Trials of risperidone, haloperidol, and quetiapine led to equivalent response, while lorazepam worsened her agitation" Kotbi N, et al. Citalopram in agitated and delusional demented patients who failed treatment with antipsychotic agents. Journal of Neuropsychiatry and Clinical Neurosciences 26: E62, No. 2, 2014. Available from: URL: http://doi.org/10.1176/ appi.neuropsych.13060122 - USA 803105860 1 Reactions 19 Jul 2014 No. 1510 0114-9954/14/1510-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
Transcript of Lorazepam
Reactions 1510, p29 - 19 Jul 2014
SLorazepam
Worsening of agitation treated with citalopram: casereport
An 84-year-old woman developed worsening of agitationduring treatment with lorazepam and was eventually treatedwith citalopram.
The woman who was acutely hospitalised due to physicalaggression and somatic delusion, received lorazepam [routeand dosage not stated]. She had also received risperidone,haloperidol and quetiapine. Later, it was found that lorazepamworsened the agitation [duration of treatment to reaction onsetnot stated].
The woman was treated with citalopram 10mg twice dailyon admission, later increased to 15mg twice daily and within72 hours, the agitation decreased dramatically. She wasdischarged soon. Later, on a follow-up, she was found in goodbehavioural control.
Author comment: "Trials of risperidone, haloperidol, andquetiapine led to equivalent response, while lorazepamworsened her agitation"Kotbi N, et al. Citalopram in agitated and delusional demented patients who failedtreatment with antipsychotic agents. Journal of Neuropsychiatry and ClinicalNeurosciences 26: E62, No. 2, 2014. Available from: URL: http://doi.org/10.1176/appi.neuropsych.13060122 - USA 803105860
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Reactions 19 Jul 2014 No. 15100114-9954/14/1510-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
