Lorazepam
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Reactions 666 - 30 Aug 1997 ★ Lorazepam First report of pharyngeal dysphagia: case report Pharyngeal dysphagia occurred in a 57-year-old woman during treatment with lorazepam [‘Lorax’]. The woman, who had rheumatoid arthritis, was receiving treatment with prednisone, and she had taken lorazepam 2mg at night for the past 2 years. She presented with a 2-week history of dysphagia, which had started as intense odynophagia in her cervical region. Since the onset of her symptoms, she had eaten only small amounts of liquid foods. A radiological study of deglutition showed partial retention of barium in the woman’s pharynx and scintigraphy showed a pharynx retention of approximately 47% of the volume swallowed. Lorazepam was discontinued and, 2 weeks later, the dysphagia had resolved. Repeat tests showed that she could easily swallow a 10ml bolus of water, without pharyngeal retention. At follow-up after 1 year, the dysphagia had not recurred. Dantas RO, et al. Dysphagia induced by chronic ingestion of benzodiazepine. American Journal of Gastroenterology 92: 1194-1196, Jul 1997 - Brazil 800555074 » Editorial comment: Dysphagia associated with other benzodiazepines has been reported previously. However, a search of AdisBase and Medline did not reveal any previous reports of dysphagia associated with lorazepam. 1 Reactions 30 Aug 1997 No. 666 0114-9954/10/0666-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Lorazepam
Reactions 666 - 30 Aug 1997
★Lorazepam
First report of pharyngeal dysphagia: case reportPharyngeal dysphagia occurred in a 57-year-old woman
during treatment with lorazepam [‘Lorax’].The woman, who had rheumatoid arthritis, was receiving
treatment with prednisone, and she had taken lorazepam 2mgat night for the past 2 years. She presented with a 2-weekhistory of dysphagia, which had started as intenseodynophagia in her cervical region. Since the onset of hersymptoms, she had eaten only small amounts of liquid foods.
A radiological study of deglutition showed partial retentionof barium in the woman’s pharynx and scintigraphy showed apharynx retention of approximately 47% of the volumeswallowed. Lorazepam was discontinued and, 2 weeks later,the dysphagia had resolved. Repeat tests showed that shecould easily swallow a 10ml bolus of water, withoutpharyngeal retention. At follow-up after 1 year, the dysphagiahad not recurred.Dantas RO, et al. Dysphagia induced by chronic ingestion of benzodiazepine.American Journal of Gastroenterology 92: 1194-1196, Jul 1997 -Brazil 800555074
» Editorial comment: Dysphagia associated with otherbenzodiazepines has been reported previously. However, asearch of AdisBase and Medline did not reveal any previousreports of dysphagia associated with lorazepam.
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Reactions 30 Aug 1997 No. 6660114-9954/10/0666-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
