Symbole graficzne aparatów, maszyn i urządzeń przemysłu chemicznego
Furosemide/oxcarbazepine
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Reactions 994 - 27 Mar 2004 Furosemide/oxcarbazepine Encephalopathy: case report Concomitant treatment with oxcarbazepine and furosemide was associated with acute encephalopathy in a 64-year-old woman. The woman, who had a 20-year history of complex partial seizures, was receiving oxcarbazepine 30 mg/kg/day (1800 mg/day) for the treatment of her seizures [duration of therapy not stated]. She then began treatment with furosemide 25 mg/day for mild hypertension. Approximately 1 month later, she presented with confusion, auditory and visual hallucinations and delirium. Investigations revealed a significant decrease in sodium and chloride levels to 115 and 81 mEq/L, respectively. An EEG showed theta activity, 14–15 Hz activity and isolated sharp waves bilaterally. Furosemide and oxcarbazepine were replaced with valproic acid and amlodipine. After 20 days, the woman was oriented, her hallucinations and delirium had resolved, and her serum sodium and chloride levels had normalised. A repeat EEG showed mild generalised background alpha activity mixed with medium-amplitude theta activity bilaterally. At follow-up 6 months later, the woman had no evidence of neurological disorders, she had normal sodium and chloride levels, and her EEG had returned to baseline showing only mild generalised background alpha activity. Author comment: "Use of the Naranjo probability scale indicated a probable relationship between neurologic manifestations and concomitant use of oxcarbazepine plus furosemide." Electrolytes should be carefully monitored in older patients treated concomitantly with furosemide and oxcarbazepine. Siniscalchi A, et al. Acute encephalopathy induced by oxcarbazepine and furosemide. Annals of Pharmacotherapy 38: 509-510, No. 3, Mar 2004 - Italy 800958683 1 Reactions 27 Mar 2004 No. 994 0114-9954/10/0994-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Furosemide/oxcarbazepine
Reactions 994 - 27 Mar 2004
Furosemide/oxcarbazepine
Encephalopathy: case reportConcomitant treatment with oxcarbazepine and furosemide
was associated with acute encephalopathy in a 64-year-oldwoman.
The woman, who had a 20-year history of complex partialseizures, was receiving oxcarbazepine 30 mg/kg/day(1800 mg/day) for the treatment of her seizures [duration oftherapy not stated]. She then began treatment with furosemide25 mg/day for mild hypertension. Approximately 1 monthlater, she presented with confusion, auditory and visualhallucinations and delirium. Investigations revealed asignificant decrease in sodium and chloride levels to 115 and81 mEq/L, respectively. An EEG showed theta activity, 14–15Hz activity and isolated sharp waves bilaterally.
Furosemide and oxcarbazepine were replaced with valproicacid and amlodipine. After 20 days, the woman was oriented,her hallucinations and delirium had resolved, and her serumsodium and chloride levels had normalised. A repeat EEGshowed mild generalised background alpha activity mixedwith medium-amplitude theta activity bilaterally. At follow-up6 months later, the woman had no evidence of neurologicaldisorders, she had normal sodium and chloride levels, and herEEG had returned to baseline showing only mild generalisedbackground alpha activity.
Author comment: "Use of the Naranjo probability scaleindicated a probable relationship between neurologicmanifestations and concomitant use of oxcarbazepine plusfurosemide." Electrolytes should be carefully monitored inolder patients treated concomitantly with furosemide andoxcarbazepine.Siniscalchi A, et al. Acute encephalopathy induced by oxcarbazepine andfurosemide. Annals of Pharmacotherapy 38: 509-510, No. 3, Mar 2004 -Italy 800958683
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Reactions 27 Mar 2004 No. 9940114-9954/10/0994-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
