Carbamazepine overdose
1
Reactions 620 - 28 Sep 1996 S Carbamazepine overdose CNS disorders: case report The following report describes a case of a carbamazepine overdose successfully treated with haemoperfusion. A 36-year-old man was hospitalised approximately 3 hours after taking an overdose of carbamazepine [dose not known] in a presumed suicide attempt; he did not take any long-term medications. He showed combativeness alternating with lethargy, and experienced grand mal seizures and myoclonic jerks. His level of consciousness varied but he responded to deep pain. His serum carbamazepine concentration was elevated at 42.8 µg/ml. Gastric lavage was performed and he was treated with activated charcoal in sorbitol via a nasogastric tube. However, about 7 hours after hospitalisation, his serum carbamazepine concentration was 54 µg/ml. The next day, the man required mechanical ventilation because of a deterioration in respiratory function. Haemoperfusion was started approximately 17 hours after hospitalisation. His serum carbamazepine concentrations decreased from 55.5 to 27.3 µg/ml during haemoperfusion and his clinical condition improved. On the second day after haemoperfusion, he was able to be extubated. Four days after hospital admission, he was transferred to a psychiatric department. Author comment: This patient had not been on chronic carbamazepine therapy. ‘This is probably the major reason why HP [haemoperfusion] proved to be useful and effective.’ Low CL, et al. Treatment of acute carbamazepine poisoning by hemoperfusion. American Journal of Emergency Medicine 14: 540-541, Sep 1996 - USA 800466279 1 Reactions 28 Sep 1996 No. 620 0114-9954/10/0620-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
-
Upload
hoangduong -
Category
Documents
-
view
212 -
download
0
Transcript of Carbamazepine overdose
Reactions 620 - 28 Sep 1996
SCarbamazepine overdose
CNS disorders: case reportThe following report describes a case of a carbamazepine
overdose successfully treated with haemoperfusion.A 36-year-old man was hospitalised approximately 3 hours
after taking an overdose of carbamazepine [dose not known] ina presumed suicide attempt; he did not take any long-termmedications. He showed combativeness alternating withlethargy, and experienced grand mal seizures and myoclonicjerks. His level of consciousness varied but he responded todeep pain. His serum carbamazepine concentration waselevated at 42.8 µg/ml. Gastric lavage was performed and hewas treated with activated charcoal in sorbitol via a nasogastrictube. However, about 7 hours after hospitalisation, his serumcarbamazepine concentration was 54 µg/ml.
The next day, the man required mechanical ventilationbecause of a deterioration in respiratory function.Haemoperfusion was started approximately 17 hours afterhospitalisation. His serum carbamazepine concentrationsdecreased from 55.5 to 27.3 µg/ml during haemoperfusionand his clinical condition improved. On the second day afterhaemoperfusion, he was able to be extubated. Four days afterhospital admission, he was transferred to a psychiatricdepartment.
Author comment: This patient had not been on chroniccarbamazepine therapy. ‘This is probably the major reason whyHP [haemoperfusion] proved to be useful and effective.’Low CL, et al. Treatment of acute carbamazepine poisoning by hemoperfusion.American Journal of Emergency Medicine 14: 540-541, Sep 1996 -USA 800466279
1
Reactions 28 Sep 1996 No. 6200114-9954/10/0620-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
