Carbamazepine
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Reactions 390 - 29 Feb 1992 ★ Carbamazepine First report of hypersensitivity with identification of human liver autoantibodies: case report Researchers form the University of Liverpool, UK, suggest ’that serum from all patients with anticonvulsant-induced hepatic injury should be screened for the presence of autoantibodies in order to help elucidate the mechanism of this rare, but potentially life-threatening adverse reaction’. Fever developed in a 16-year-old man 4 weeks after carbamazepine 400 mg/day was initiated to control epilepsy. A rash occurred 1 week later, and jaundice appeared within another week Liver enzyme function was elevated and eosinophilia was observed Carbamazepine-induced hepatotoxicity was suspected and carbamazepine was withdrawn. The patient recovered within 6 weeks. Serum samples taken at the time of this patient’s reaction revealed autoantibodies recognising a protein band from human liver microsomes. Further samples taken 2 and 6 months after the reaction showed a diminished titre for these antibodies Pirmohamed M, et al. Detection of an autoantibody directed against human liver microsomal protein in a patient with carbamazepine hypersensitivity. Journal of Clinical Pharmacology 33: 183-186, Feb 1992 - England 800120034 1 Reactions 29 Feb 1992 No. 390 0114-9954/10/0390-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 390 - 29 Feb 1992
★Carbamazepine
First report of hypersensitivity with identification ofhuman liver autoantibodies: case report
Researchers form the University of Liverpool, UK, suggest’that serum from all patients with anticonvulsant-inducedhepatic injury should be screened for the presence ofautoantibodies in order to help elucidate the mechanism ofthis rare, but potentially life-threatening adverse reaction’.
Fever developed in a 16-year-old man 4 weeks aftercarbamazepine 400 mg/day was initiated to control epilepsy. Arash occurred 1 week later, and jaundice appeared withinanother week
Liver enzyme function was elevated and eosinophilia wasobserved Carbamazepine-induced hepatotoxicity wassuspected and carbamazepine was withdrawn. The patientrecovered within 6 weeks.
Serum samples taken at the time of this patient’s reactionrevealed autoantibodies recognising a protein band fromhuman liver microsomes. Further samples taken 2 and 6months after the reaction showed a diminished titre for theseantibodiesPirmohamed M, et al. Detection of an autoantibody directed against human livermicrosomal protein in a patient with carbamazepine hypersensitivity. Journal ofClinical Pharmacology 33: 183-186, Feb 1992 - England 800120034
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Reactions 29 Feb 1992 No. 3900114-9954/10/0390-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
