Carbamazepine
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Carbamazepine Adverse fetal effects: incidence study The effects of in utero ca rbamazepine exposure were assessed retrospectively in 8 children and prospectively in 72 women who received carbamazepine during pregnancy. Of the 8 retrospecti ve ly assessed children , 4 were exposed to ca rbamazepine alone, 2 to carbamazepine and phenobarbital, to carbamazepine and primidone and 1 to ca rbamazepine, phenobarbital and clonazepam. Two of the 8 child ren were shown to have prenatal growth deficiency: difficulties in feeding , disorganised breathing , hypoventilation and tremulousness were observed in 3 children . Postnatal growth deficiency occurred in 3 of the 4 children followed up for > 1 year and involved a developmental quotient of 50 in 2 children and an intelligence quotient of 60 in 1 child . Of the prospectively assessed pregnancies , 50 women took ca rbamazepine al one , and others received adjuvant phenobarbital and valproic acid (n = 4) , primidone (3), valproic acid (1) , ethosuximide (1) and primidone and ethosuximide (1). Carbamazepine dosage ranged from 200 to 1200 mg/day. 59% of women experienced at least 1 seizure during pregnancy. 54 infants were born live, and 48 of these were evaluated. Two children had a cleft uvula following exposure to carbamazepine and phenobarbital. Of the children exposed to carbamazepine only, 1 had a lumbosacral meningomyelocele, 1 had multiple ventricular septal defects, corrected by surgery, and 1 an indirect inguinal hernia. 5 of 25 children exposed to carbamazepine alone had delays in mental or psychomotor development. 2 of 4 children exposed to carbamazepine, phenobarbital and valproic acid exhibited delayed development. Although the frequency of carbamazepine-induced adverse fetal effects cannot be determined from these results, they do suggest that carbamazepine ' .. . may well present a significant risk to the unborn baby'. Jones KL . Lacro RV . Johnson KA. Adams J Pattern of malformations ,n the children of women Ireated with carbamazeplne dUring pregnancy. New England Journal of MediCine 320 . 1661 · 1666, 22 Jun t 989 '''' Systemic lupus erythematosus: case report Drory VE . Yust I. Korczyn AD . Carbamazeplne· Induced systemic lupus erythematosus Clinical Neuropharmacology 12 t t 5· 118. Feb 1989 [27 references J ,m
Transcript of Carbamazepine
Carbamazepine Adverse fetal effects: incidence study
The effects of in utero carbamazepine exposure were assessed retrospectively in 8 children and prospectively in 72 women who received carbamazepine during pregnancy.
Of the 8 retrospectively assessed children , 4 were exposed to carbamazepine alone, 2 to carbamazepine and phenobarbital , to carbamazepine and primidone and 1 to carbamazepine , phenobarbital and clonazepam.
Two of the 8 child ren were shown to have prenatal growth deficiency: difficulties in feeding , disorganised breathing , hypoventilation and tremulousness were observed in 3 children . Postnatal growth deficiency occurred in 3 of the 4 children followed up for > 1 year and involved a developmental quotient of 50 in 2 children and an intelligence quotient of 60 in 1 child .
Of the prospectively assessed pregnancies , 50 women took carbamazepine alone, and others received adjuvant phenobarbital and valproic acid (n = 4) , primidone (3), valproic acid (1) , ethosuximide (1) and primidone and ethosuximide (1). Carbamazepine dosage ranged from 200 to 1200 mg/day. 59% of women experienced at least 1 seizure during pregnancy. 54 infants were born live, and 48 of these were evaluated . Two children had a cleft uvula following exposure to carbamazepine and phenobarbital. Of the children exposed to carbamazepine only , 1 had a lumbosacral meningomyelocele, 1 had multiple ventricular septal defects, corrected by surgery, and 1 an indirect inguinal hernia. 5 of 25 children exposed to carbamazepine alone had delays in mental or psychomotor development. 2 of 4 children exposed to carbamazepine, phenobarbital and valproic acid exhibited delayed development .
Although the frequency of carbamazepine-induced adverse fetal effects cannot be determined from these results , they do suggest that carbamazepine ' .. . may well present a significant risk to the unborn baby'.
Jones KL. Lacro RV. Johnson KA. Adams J Pattern of malformations ,n the children of women Ireated with carbamazeplne dUring pregnancy. New England Journal of MediCine 320. 1661 ·1666, 22 Jun t 989 ''''
Systemic lupus erythematosus: case report Drory VE . Yust I. Korczyn AD. Carbamazeplne· Induced systemic lupus erythematosus Clinical Neuropharmacology 12 t t 5·118. Feb 1989 [27 references J ,m
