Carbamazepine
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Carbamazepine Eosinophilia: incidence study 653 patients receiving carbamazepine for various reasons, mostly epilepsy, had white blood cell and differential counts every 2 months, 36 patients (5 ,5%) aged 2-50 (mean 18, 6) years and comprising 22 females and 14 males, developed eosinophilia (> 7% leucocytes, mean 9.2%), Carbamazepine had been taken for 3-48 (mean 14, 3) months with blood concentrations of 3-12 (mean 7,4) "g/ml. There were no concomitant medical conditions in these patients which could account for the high eosinophil count. The differential count resolved in 5 patients but remained high in the rest. 'Our study suggests that eosinophilia occurs in about 1 in 20 patients undergoing long-term carbamazepine treatment.' De Marco p, Melchior; G. Annals of Neurology 20: 274, Aug 1986 6 Reactions" 18 Oct 1986 0157-7271/86/1018.()()()6/ 0$OI,OO/O © ADIS Press
Transcript of Carbamazepine
Carbamazepine Eosinophilia: incidence study
653 patients receiving carbamazepine for various reasons, mostly epilepsy, had white blood cell and differential counts every 2 months,
36 patients (5,5%) aged 2-50 (mean 18,6) years and comprising 22 females and 14 males, developed eosinophilia (> 7% leucocytes, mean 9.2%), Carbamazepine had been taken for 3-48 (mean 14,3) months with blood concentrations of 3-12 (mean 7,4) "g/ml. There were no concomitant medical conditions in these patients which could account for the high eosinophil count. The differential count resolved in 5 patients but remained high in the rest.
'Our study suggests that eosinophilia occurs in about 1 in 20 patients undergoing long-term carbamazepine treatment.' De Marco p, Melchior; G. Annals of Neurology 20: 274, Aug 1986
6 Reactions" 18 Oct 1986 0157-7271/86/1018.()()()6/ 0$OI ,OO/O © ADIS Press
