Carbamazepine
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Carbamazepine Double quotidian fefer A patient with nQ other adverse reactions or evidence of hypersensitivity developed twice- daily fevers while taking carbamazepine. The 62-year-old woman had a long history of seizures after cerebral infarction, which were inadequately controlled with phenytoin ('Dilantin'). Two days after adding carbamazepine (800mg I day) the fevers began. When the drug was withdrawn, they stopped. With lower doses, the fever returned but was not as high as before. On raising the dose to 800mgl day, her temperature rose to 40"C twice daily. When carbamazepine was stopped, the fevers disappeared. Stewart. C. R. el ai.e New England Journal or Medicine .102, 1262 (29 May 198D) Severe poisoning from ingestion ofonly 109 Following a suicide attempt with 109 carbamazepine, 2.Sg aspirin and 2.5g phenacetin. a 26-year-old man was admitted to hospital. He was drowsy with systolic BP 150mm Hg and pulse rate \00/ min. Stomach aspiration showed no sign of tablets. The patient became stuporous with minor convulsions, chorea-like movements and nystagmus. His respiration was inadequate so artificial ventilation was given through a nasogastric tUbe. Forced diuresis and alkalinization of the urine was started. The diuresis was stopped after 2 hours when the serum aspirin level was < 0.2mmol/L. The man was kept sedated with d-tubocurarine. The next day the serum bilirubin level was increased but no renal complications developed from the hemolysis. The admission blood level of carbamazepine was > 2001lmol/L. 88 hours after admission the patient was transferred to the psychiatric ward. Drenck. N.E. and Risbo. A ,Anaesthesia and Intensive Care 8, 203 (May 1980) 4 ReacttonS Jun 'n 1980 0157-7271/80/0627-0004/0 $00.50/0 © ADIS PreSS
Transcript of Carbamazepine
Carbamazepine
Double quotidian fefer A patient with nQ other adverse reactions or evidence of hypersensitivity developed twicedaily fevers while taking carbamazepine. The 62-year-old woman had a long history of seizures after cerebral infarction, which were inadequately controlled with phenytoin ('Dilantin'). Two days after adding carbamazepine (800mg I day) the fevers began. When the drug was withdrawn, they stopped. With lower doses, the fever returned but was not as high as before. On raising the dose to 800mgl day, her temperature rose to 40"C twice daily. When carbamazepine was stopped, the fevers disappeared. Stewart. C. R. el ai.e New England Journal or Medicine .102, 1262 (29 May 198D)
Severe poisoning from ingestion ofonly 109 Following a suicide attempt with 109 carbamazepine, 2.Sg aspirin and 2.5g phenacetin. a 26-year-old man was admitted
to hospital. He was drowsy with systolic BP 150mm Hg and pulse rate \00/ min. Stomach aspiration showed no sign of tablets. The patient became stuporous with minor convulsions, chorea-like movements and nystagmus. His respiration was inadequate so artificial ventilation was given through a nasogastric tUbe. Forced diuresis and alkalinization of the urine was started. The diuresis was stopped after 2 hours when the serum aspirin level was < 0.2mmol/L. The man was kept sedated with d-tubocurarine. The next day the serum bilirubin level was increased but no renal complications developed from the hemolysis. The admission blood level of carbamazepine was > 2001lmol/L. 88 hours after admission the patient was transferred to the psychiatric ward. Drenck. N.E. and Risbo. A ,Anaesthesia and Intensive Care 8, 203 (May 1980)
4 ReacttonS Jun 'n 1980 0157-7271/80/0627-0004/0 $00.50/0 © ADIS PreSS
