Carbamazepine
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Reactions 1416 - 25 Aug 2012 S Carbamazepine Phocomelia and club foot in a newborn following in utero exposure: case report A male neonate was born with bilateral phocomelia and club foot following in utero exposure to carbamazepine. The baby’s mother, who was 29-years-old, had been receiving carbamazepine 800 mg/day for epilepsy throughout pregnancy [parental route not stated], and gave birth to a male baby at 40 weeks gestation. The baby presented at age 26 days with a diagnosis of congenital anomaly. Examination revealed four short and deformed limbs, with the absence of both thumbs, low-set ears, bilateral pes equinovarus, a mid-line facial haemangioma, high palate and restricted hip movement. X-ray revealed absence of the radius and ulna in both arm extremities, a shortened tibia and absent fibulae. The baby was subsequently discharged [outcome not stated]. Author comment: "In this report, we present a newborn persistently exposed to carbamazepine during pregnancy and diagnosed as bilateral phocomelia and club foot." Dursun A, et al. Carbamazepine use in pregnancy and coincidental thalidomide- like phocomelia in a newborn. Journal of Obstetrics and Gynaecology (England) 32: 488-489, No. 5, Jul 2012. Available from: URL: http:// dx.doi.org/10.3109/01443615.2012.673037 - Turkey 803075862 1 Reactions 25 Aug 2012 No. 1416 0114-9954/10/1416-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 1416 - 25 Aug 2012
SCarbamazepine
Phocomelia and club foot in a newborn followingin utero exposure: case report
A male neonate was born with bilateral phocomelia andclub foot following in utero exposure to carbamazepine.
The baby’s mother, who was 29-years-old, had beenreceiving carbamazepine 800 mg/day for epilepsythroughout pregnancy [parental route not stated], and gavebirth to a male baby at 40 weeks gestation. The babypresented at age 26 days with a diagnosis of congenitalanomaly. Examination revealed four short and deformedlimbs, with the absence of both thumbs, low-set ears,bilateral pes equinovarus, a mid-line facial haemangioma,high palate and restricted hip movement. X-ray revealedabsence of the radius and ulna in both arm extremities, ashortened tibia and absent fibulae. The baby wassubsequently discharged [outcome not stated].
Author comment: "In this report, we present a newbornpersistently exposed to carbamazepine during pregnancy anddiagnosed as bilateral phocomelia and club foot."Dursun A, et al. Carbamazepine use in pregnancy and coincidental thalidomide-like phocomelia in a newborn. Journal of Obstetrics and Gynaecology (England)32: 488-489, No. 5, Jul 2012. Available from: URL: http://dx.doi.org/10.3109/01443615.2012.673037 - Turkey 803075862
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Reactions 25 Aug 2012 No. 14160114-9954/10/1416-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
