Carbamazepine
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Reactions 1516, p50 - 30 Aug 2014 S Carbamazepine Osteomalacia: case report A 32-year-old woman developed osteomalacia following treatment with carbamazepine for bipolar disorder. The woman was referred due to inability to walk resulting from pain and weakness in the left leg for the past 3 months. For the last 10 years, she was receiving carbamazepine [route and dosage not stated] for mental illness. Examination revealed significant proximal muscle weakness in the legs with an antalgic gait. Tests showed the following values: carbamazepine level 7.67 µg/mL, corrected calcium 8.0 mg%, phosphorus 2 mg%, 25-hydroxyvitamin D3 3 ng/mL, parathyroid hormone 501 pg/mL and ALP 685 U/L. Carbamazepine-induced osteomalacia was diagnosed. A pelvic x-ray revealed a Looser zone. Cholecalciferol and calcium were initiated. At follow-up, after 3 months, tests revealed the following values: phosphorus 4.4 mg%, serum calcium 8.6 mg% and serum ALP 373 U/L. Callus formation was observed on pelvic x-ray. Author comment: "Although multiple factors may be responsible, in this patient osteomalacia was probably due to carbamazepine." Shetty SP, et al. Visual vignette. Carbamazapine-induced osteomalacia. Endocrine Practice 19: 738, No. 4, Jul-Aug 2013 - India 803107393 1 Reactions 30 Aug 2014 No. 1516 0114-9954/14/1516-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 1516, p50 - 30 Aug 2014
SCarbamazepine
Osteomalacia: case reportA 32-year-old woman developed osteomalacia following
treatment with carbamazepine for bipolar disorder.The woman was referred due to inability to walk resulting
from pain and weakness in the left leg for the past 3 months.For the last 10 years, she was receiving carbamazepine [routeand dosage not stated] for mental illness. Examination revealedsignificant proximal muscle weakness in the legs with anantalgic gait. Tests showed the following values:carbamazepine level 7.67 µg/mL, corrected calcium 8.0 mg%,phosphorus 2 mg%, 25-hydroxyvitamin D3 3 ng/mL,parathyroid hormone 501 pg/mL and ALP 685 U/L.Carbamazepine-induced osteomalacia was diagnosed. Apelvic x-ray revealed a Looser zone.
Cholecalciferol and calcium were initiated. At follow-up,after 3 months, tests revealed the following values:phosphorus 4.4 mg%, serum calcium 8.6 mg% and serum ALP373 U/L. Callus formation was observed on pelvic x-ray.
Author comment: "Although multiple factors may beresponsible, in this patient osteomalacia was probably due tocarbamazepine."Shetty SP, et al. Visual vignette. Carbamazapine-induced osteomalacia. EndocrinePractice 19: 738, No. 4, Jul-Aug 2013 - India 803107393
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Reactions 30 Aug 2014 No. 15160114-9954/14/1516-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
