Carbamazepine
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Reactions 1398 - 21 Apr 2012 S Carbamazepine Thrombocytopenia: case report A 21-year-old woman developed thrombocytopenia following treatment with carbamazepine [therapeutic indication not stated]. The woman, who had a history of bipolar disorder, presented with a 4-day history of pyrexia, significant thrombocytopenia and petechial rash. Examination revealed a petechial rash on her lower legs. Tests showed the following values: platelet count of 4 K/µL, Hg 13.1 mg/dL and WBC count of 3 K/µL. Prednisone and ceftriaxone were initiated. The woman reported that she was receiving carbamazepine 200mg twice daily [route not stated], which had been administered for the past month. Carbamazepine was withdrawn, and platelets were transfused. Her platelet increased to 46 K/µL, yet subsequently dropped to 12 K/µL. Over the next few days, her platelet count reached 161 K/µL. Author comment: "In our case carbamezapine was the "probable" cause of thrombocytopenia as per criteria defined by George et el [sic] in the literature." Zahoor H, et al. Carbamezapine as a rare cause of thrombocytopenia. Journal of General Internal Medicine 26: S464, May 2011. Available from: URL: http:// dx.doi.org/10.1007/s11606-011-1730-9 [abstract] - USA 803069435 1 Reactions 21 Apr 2012 No. 1398 0114-9954/10/1398-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 1398 - 21 Apr 2012
SCarbamazepine
Thrombocytopenia: case reportA 21-year-old woman developed thrombocytopenia
following treatment with carbamazepine [therapeuticindication not stated].
The woman, who had a history of bipolar disorder,presented with a 4-day history of pyrexia, significantthrombocytopenia and petechial rash. Examinationrevealed a petechial rash on her lower legs. Tests showedthe following values: platelet count of 4 K/µL, Hg13.1 mg/dL and WBC count of 3 K/µL.
Prednisone and ceftriaxone were initiated. The womanreported that she was receiving carbamazepine 200mgtwice daily [route not stated], which had been administeredfor the past month. Carbamazepine was withdrawn, andplatelets were transfused. Her platelet increased to 46 K/µL,yet subsequently dropped to 12 K/µL. Over the next fewdays, her platelet count reached 161 K/µL.
Author comment: "In our case carbamezapine was the"probable" cause of thrombocytopenia as per criteria definedby George et el [sic] in the literature."Zahoor H, et al. Carbamezapine as a rare cause of thrombocytopenia. Journal ofGeneral Internal Medicine 26: S464, May 2011. Available from: URL: http://dx.doi.org/10.1007/s11606-011-1730-9 [abstract] - USA 803069435
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Reactions 21 Apr 2012 No. 13980114-9954/10/1398-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
