Symbole graficzne aparatów, maszyn i urządzeń przemysłu chemicznego
Benazepril
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Reactions 915 - 17 Aug 2002 ★ S Benazepril First report of fatal fetal disorders following in utero exposure: case report A female neonate was born with hypocalvaria and subsequently developed renal failure following in utero exposure to benazepril [‘Lotensin’]. The girl was born at 32 weeks’ gestation by caesarean section for possible abruption. The mother had chronic hypertension and her medication was changed from hydrochlorothiazide to benazepril [dosage not stated] at 8 weeks’ gestation and was discontinued 1 week prior to delivery; she subsequently developed oligohydramnios. Examination of the neonate revealed large fontanelles due to abnormally small calvarial bones, flattened spade-like hands and severe eversion of her left foot and calcaneovagus. A renal ultrasound revealed increased echogenicity of her kidneys with poor demarcation of the pyramids. Her creatinine level increased after birth but she had good urine output. At 1 week of age the girl developed Pseudomonal sepsis with coagulopathy, hypotension and oliguria. She died at age 28 days. Author comment: ‘In review of the literature, a triad of hypocalvaria, renal tubular dysplasia and oligohydramnios have been reported with other ACE inhibitors but not with benazepril.’ Robinson LK, et al. A case of maternal use of the ace inhibitor benazepril (Lotensin) during pregnancy resulting in oligohydramnios, hypocalvaria, and renal failure. Hypertension in Pregnancy 21 (Suppl. 1): 130, 2002 [abstract] - USA 800909586 » Editorial comment: A search of AdisBase, Medline and the WHO Adverse Drug Reactions database did not reveal any previous case reports of neonatal or fetal disorders associated with benazepril. 1 Reactions 17 Aug 2002 No. 915 0114-9954/10/0915-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Benazepril
Reactions 915 - 17 Aug 2002
★ SBenazepril
First report of fatal fetal disorders following in uteroexposure: case report
A female neonate was born with hypocalvaria andsubsequently developed renal failure following in uteroexposure to benazepril [‘Lotensin’].
The girl was born at 32 weeks’ gestation by caesareansection for possible abruption. The mother had chronichypertension and her medication was changed fromhydrochlorothiazide to benazepril [dosage not stated] at 8weeks’ gestation and was discontinued 1 week prior todelivery; she subsequently developed oligohydramnios.Examination of the neonate revealed large fontanelles due toabnormally small calvarial bones, flattened spade-like handsand severe eversion of her left foot and calcaneovagus. A renalultrasound revealed increased echogenicity of her kidneyswith poor demarcation of the pyramids. Her creatinine levelincreased after birth but she had good urine output.
At 1 week of age the girl developed Pseudomonal sepsiswith coagulopathy, hypotension and oliguria. She died at age28 days.
Author comment: ‘In review of the literature, a triad ofhypocalvaria, renal tubular dysplasia and oligohydramnios havebeen reported with other ACE inhibitors but not withbenazepril.’Robinson LK, et al. A case of maternal use of the ace inhibitor benazepril(Lotensin) during pregnancy resulting in oligohydramnios, hypocalvaria, and renalfailure. Hypertension in Pregnancy 21 (Suppl. 1): 130, 2002 [abstract] -USA 800909586
» Editorial comment: A search of AdisBase, Medline and theWHO Adverse Drug Reactions database did not reveal anyprevious case reports of neonatal or fetal disorders associatedwith benazepril.
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Reactions 17 Aug 2002 No. 9150114-9954/10/0915-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
