Antineoplastics
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Reactions 439 - 20 Feb 1993 Antineoplastics Cognition disorders: incidence study An American study of children with acute lymphocytic leukaemia who were at various stages of their antineoplastic therapy, found those who had completed the 3-year regimen had the most impairment in their cognitive functioning. Children aged 4-17 years, who were in their first remission, were either newly-diagnosed (Group 1; n = 19), had received 1 year’s therapy (Group 2; 18) or had completed 3 years’ therapy (Group 3; 11). Antineoplastic therapy included asparaginase, cyclophosphamide, methotrexate, cytarabine, prednisone and mercaptopurine. No children received radiation therapy as CNS prophylaxis. More children from Group 3 were designated as learning disabled (60%) compared with Group 1 (0) or Group 2 (15.4%). Group 3 children performed significantly more poorly than the other 2 groups in terms of perception and organisation of stimuli, short-term memory and focused attention and complex motor skills including eye-hand activities Brown RT, et al. Chemotherapy for acute lymphocytic leukemia: cognitive and academic sequelae. Journal of Pediatrics 121: 885-889, Dec 1992 - USA 800177415 1 Reactions 20 Feb 1993 No. 439 0114-9954/10/0439-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 439 - 20 Feb 1993
Antineoplastics
Cognition disorders: incidence studyAn American study of children with acute lymphocytic
leukaemia who were at various stages of their antineoplastictherapy, found those who had completed the 3-year regimenhad the most impairment in their cognitive functioning.Children aged 4-17 years, who were in their first remission,were either newly-diagnosed (Group 1; n = 19), had received1 year’s therapy (Group 2; 18) or had completed 3 years’therapy (Group 3; 11). Antineoplastic therapy includedasparaginase, cyclophosphamide, methotrexate, cytarabine,prednisone and mercaptopurine. No children receivedradiation therapy as CNS prophylaxis. More children fromGroup 3 were designated as learning disabled (60%) comparedwith Group 1 (0) or Group 2 (15.4%). Group 3 childrenperformed significantly more poorly than the other 2 groups interms of perception and organisation of stimuli, short-termmemory and focused attention and complex motor skillsincluding eye-hand activitiesBrown RT, et al. Chemotherapy for acute lymphocytic leukemia: cognitive andacademic sequelae. Journal of Pediatrics 121: 885-889, Dec 1992 -USA 800177415
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Reactions 20 Feb 1993 No. 4390114-9954/10/0439-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
