Antineoplastics
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Reactions 434 - 16 Jan 1993 S Antineoplastics Neutropenic enterocolitis: case report Neutropenic enterocolitis complicated by intestinal perforation developed in a 50-year-old woman who underwent conditioning with thiotepa, carboplatin, etoposide, carmustine and melphalan prior to autologous bone marrow transplantation (ABMT) following surgery and antineoplastic therapy for breast cancer. After the transplant she received granulocyte colony-stimulating factor. The day before ABMT the patient developed marked diarrhoea and vomiting. The vomiting was controlled with symptomatic therapy, but the diarrhoea worsened. The patient subsequently developed fever on day 4 after ABMT and was treated empirically with antibacterials. Fever and diarrhoea persisted despite therapy. On day 8 after ABMT, the patient developed severe abdominal pain. An abdominal x-ray showed gas under the diaphragm. Shortly afterwards she developed hypotension and shock and death ensued. At the time of death, the patient’s leucocyte count was 0.4 × 10 9 /L with almost all cells being granulocytes. Author comment: A case of neutropenic enterocolitis associated with carboplatin has been reported previously. The other antineoplastic agents which were given to this woman are not usually severely toxic to the GI mucosa. Mehta J, et al. Neutropenic enterocolitis and intestinal perforation associated with carboplatin-containing conditioning regimen for autologous bone marrow transplantation. Acta Oncologica 31: 591, No. 5, 1992 - Israel 800166782 1 Reactions 16 Jan 1993 No. 434 0114-9954/10/0434-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Antineoplastics
Reactions 434 - 16 Jan 1993
SAntineoplastics
Neutropenic enterocolitis: case reportNeutropenic enterocolitis complicated by intestinal
perforation developed in a 50-year-old woman whounderwent conditioning with thiotepa, carboplatin, etoposide,carmustine and melphalan prior to autologous bone marrowtransplantation (ABMT) following surgery and antineoplastictherapy for breast cancer. After the transplant she receivedgranulocyte colony-stimulating factor.
The day before ABMT the patient developed markeddiarrhoea and vomiting. The vomiting was controlled withsymptomatic therapy, but the diarrhoea worsened. The patientsubsequently developed fever on day 4 after ABMT and wastreated empirically with antibacterials. Fever and diarrhoeapersisted despite therapy.
On day 8 after ABMT, the patient developed severeabdominal pain. An abdominal x-ray showed gas under thediaphragm. Shortly afterwards she developed hypotension andshock and death ensued. At the time of death, the patient’sleucocyte count was 0.4 × 109/L with almost all cells beinggranulocytes.
Author comment: A case of neutropenic enterocolitisassociated with carboplatin has been reported previously. Theother antineoplastic agents which were given to this woman arenot usually severely toxic to the GI mucosa.Mehta J, et al. Neutropenic enterocolitis and intestinal perforation associated withcarboplatin-containing conditioning regimen for autologous bone marrowtransplantation. Acta Oncologica 31: 591, No. 5, 1992 - Israel 800166782
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Reactions 16 Jan 1993 No. 4340114-9954/10/0434-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
