Antineoplastics
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Reactions 1391 - 3 Mar 2012 S Antineoplastics Fatal septic infections: 2 case reports A study identified two boys with acute lymphoid leukaemia (ALL) and ataxia telangiectasia who died of chemotherapy-associated septic infections. A 17-year-old boy was diagnosed with ALL and began receiving ALL-BFM-MR PRED therapy with some dosage modifications. Daunorubicin was given at 66–75%, cyclophosphamide at 75%, methotrexate at 20–100%, and doxorubicin at 75% [other drug details not stated]. Six months after diagnosis, during protocol II, he died of treatment-associated septic infection. A 13-year-old boy was diagnosed with ALL and began receiving ALL-BFM HR PRED therapy with some dosage modifications. Vincristine was given at 66%–75%, asparaginase at 66%–75%, cyclophosphamide 50% and 66%, cytarabine at 50%, mercaptopurine at 50%, and methotrexate at 20%–66% [other drug details not stated]. He died of treatment-associated septic infection 1.6 years after diagnosis. Bienemann K, et al. Promising therapy results for lymphoid malignancies in children with chromosomal breakage syndromes (Ataxia teleangiectasia or Nijmegen-breakage syndrome): A retrospective survey. British Journal of Haematology 155: 468-476, No. 4, Nov 2011. Available from: URL: http:// dx.doi.org/10.1111/j.1365-2141.2011.08863.x - Germany 803067564 1 Reactions 3 Mar 2012 No. 1391 0114-9954/10/1391-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1391 - 3 Mar 2012
SAntineoplastics
Fatal septic infections: 2 case reportsA study identified two boys with acute lymphoid
leukaemia (ALL) and ataxia telangiectasia who died ofchemotherapy-associated septic infections.
A 17-year-old boy was diagnosed with ALL and beganreceiving ALL-BFM-MR PRED therapy with some dosagemodifications. Daunorubicin was given at 66–75%,cyclophosphamide at 75%, methotrexate at 20–100%, anddoxorubicin at 75% [other drug details not stated]. Sixmonths after diagnosis, during protocol II, he died oftreatment-associated septic infection.
A 13-year-old boy was diagnosed with ALL and beganreceiving ALL-BFM HR PRED therapy with some dosagemodifications. Vincristine was given at 66%–75%,asparaginase at 66%–75%, cyclophosphamide 50% and66%, cytarabine at 50%, mercaptopurine at 50%, andmethotrexate at 20%–66% [other drug details not stated].He died of treatment-associated septic infection 1.6 yearsafter diagnosis.Bienemann K, et al. Promising therapy results for lymphoid malignancies inchildren with chromosomal breakage syndromes (Ataxia teleangiectasia orNijmegen-breakage syndrome): A retrospective survey. British Journal ofHaematology 155: 468-476, No. 4, Nov 2011. Available from: URL: http://dx.doi.org/10.1111/j.1365-2141.2011.08863.x - Germany 803067564
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Reactions 3 Mar 2012 No. 13910114-9954/10/1391-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
