Antineoplastics
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Reactions 1430 - 1 Dec 2012 S Antineoplastics Pneumatosis intestinalis: case report An 18-year-old man developed pneumatosis intestinalis following treatment with prednisolone, daunorubicin, vincristine, asparaginase and methotrexate [dosages and not all routes stated] for B lymphoblastic leukaemia. The man was hospitalised for consolidation chemotherapy; two months earlier, he received prednisolone, vincristine, asparaginase, intrathecal methotrexate and daunorubicin, an induction regimen, for B lymphoblastic leukaemia. Routine x-rays showed intraperitoneal free air with gas collection along the colon wall. Examination found mild abdominal distension. Tests showed the following values: haemoglobin 9.9 g/dL, leukocyte count 8.0 × 10 9 /L (87% neutrophils) and platelet count 278 × 10 9 /L. Extramural and intramural gas of the transverse and ascending colon was observed by CT in addition to pneumoretroperitoneum and pneumoperitoneum. He was diagnosed with pneumatosis intestinalis. Ceftazidime, teicoplanin and metronidazole were initiated. The man’s condition subsequently improved; repeat imaging, 2 weeks later, revealed significant regression of pneumatosis intestinalis with resolution noted after 4 weeks. Symptoms of acute lymphoblastic leukaemia ensued after a few days necessitating successful readministration of vincristine. Author comment: "[W]e report a rare case of asymptomatic PI [pneumatosis intestinalis] in an 18-yr-old man after induction of chemotherapy for B lymphoblastic leukemia". Shin D-K, et al. Asymptomatic pneumatosis intestinalis following chemotherapy for B lymphoblastic leukemia with recurrent genetic abnormalities in an adolescent patient. Korean Journal of Hematology 47: 74-76, No. 1, Mar 2012. Available from: URL: http://dx.doi.org/10.5045/kjh.2012.47.1.74 - South Korea 803080516 1 Reactions 1 Dec 2012 No. 1430 0114-9954/10/1430-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1430 - 1 Dec 2012
SAntineoplastics
Pneumatosis intestinalis: case reportAn 18-year-old man developed pneumatosis intestinalis
following treatment with prednisolone, daunorubicin,vincristine, asparaginase and methotrexate [dosages andnot all routes stated] for B lymphoblastic leukaemia.
The man was hospitalised for consolidationchemotherapy; two months earlier, he receivedprednisolone, vincristine, asparaginase, intrathecalmethotrexate and daunorubicin, an induction regimen, forB lymphoblastic leukaemia. Routine x-rays showedintraperitoneal free air with gas collection along the colonwall. Examination found mild abdominal distension. Testsshowed the following values: haemoglobin 9.9 g/dL,leukocyte count 8.0 × 109/L (87% neutrophils) and plateletcount 278 × 109/L. Extramural and intramural gas of thetransverse and ascending colon was observed by CT inaddition to pneumoretroperitoneum andpneumoperitoneum. He was diagnosed with pneumatosisintestinalis.
Ceftazidime, teicoplanin and metronidazole wereinitiated. The man’s condition subsequently improved;repeat imaging, 2 weeks later, revealed significantregression of pneumatosis intestinalis with resolutionnoted after 4 weeks. Symptoms of acute lymphoblasticleukaemia ensued after a few days necessitating successfulreadministration of vincristine.
Author comment: "[W]e report a rare case ofasymptomatic PI [pneumatosis intestinalis] in an 18-yr-oldman after induction of chemotherapy for B lymphoblasticleukemia".Shin D-K, et al. Asymptomatic pneumatosis intestinalis following chemotherapyfor B lymphoblastic leukemia with recurrent genetic abnormalities in an adolescentpatient. Korean Journal of Hematology 47: 74-76, No. 1, Mar 2012. Availablefrom: URL: http://dx.doi.org/10.5045/kjh.2012.47.1.74 - South Korea 803080516
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Reactions 1 Dec 2012 No. 14300114-9954/10/1430-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
