Antineoplastics
1
Reactions 1311 - 24 Jul 2010 ★ Antineoplastics Lipomatosis? (first report for procarbazine, vincristine and chlormethine): case report A 53-year-old man presented with multiple, subcutaneous mobile lesions on his arms and torso, consistent with lipomas. The lesions had developed subsequent to receiving MOPP chemotherapy with chlormethine, vincristine, procarbazine and prednisolone [routes, dosages and time to reaction onset not stated] for Hodgkin’s lymphoma; he completed chemotherapy in 1986. One lipoma on his left arm had become asymptomatic, and required enucleation under local anaesthetic. Subsequent histology was indicative of angiolipoma [patient outcome not stated]. Author comment: "The exact aetiology of this patient’s new onset lipomatosis is unknown." Cronin PA, et al. Lipomatosis: An unusual side-effect of cytotoxic chemotherapy?. Acta Dermato-Venereologica 90: 303-304, No. 3, Jan 2010. Available from: URL: http://dx.doi.org/10.2340/00015555-0823 - Ireland 803028024 » Editorial comment: A search of AdisBase, Embase, Medline and the WHO ADR database did not reveal any previous case reports of lipomatosis associated with procarbazine, vincristine or chlormethine. 1 Reactions 24 Jul 2010 No. 1311 0114-9954/10/1311-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1311 - 24 Jul 2010
★Antineoplastics
Lipomatosis? (first report for procarbazine,vincristine and chlormethine): case report
A 53-year-old man presented with multiple,subcutaneous mobile lesions on his arms and torso,consistent with lipomas. The lesions had developedsubsequent to receiving MOPP chemotherapy withchlormethine, vincristine, procarbazine and prednisolone[routes, dosages and time to reaction onset not stated] forHodgkin’s lymphoma; he completed chemotherapy in1986. One lipoma on his left arm had becomeasymptomatic, and required enucleation under localanaesthetic. Subsequent histology was indicative ofangiolipoma [patient outcome not stated].
Author comment: "The exact aetiology of this patient’snew onset lipomatosis is unknown."Cronin PA, et al. Lipomatosis: An unusual side-effect of cytotoxic chemotherapy?.Acta Dermato-Venereologica 90: 303-304, No. 3, Jan 2010. Available from: URL:http://dx.doi.org/10.2340/00015555-0823 - Ireland 803028024
» Editorial comment: A search of AdisBase, Embase,Medline and the WHO ADR database did not reveal anyprevious case reports of lipomatosis associated withprocarbazine, vincristine or chlormethine.
1
Reactions 24 Jul 2010 No. 13110114-9954/10/1311-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
