Antineoplastics
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Reactions 1194 - 22 Mar 2008 Antineoplastics Monodermatomal herpes zoster following breast reconstruction surgery: case report A 45-year-old woman, who had recently undergone breast reconstruction surgery, developed monodermatomal herpes zoster during treatment with antineoplastics [specific drugs and dosages not stated]. The woman was diagnosed with new stage III breast cancer and underwent modified radical mastectomy, followed by transverse rectus abdominis myocutaneous (TRAM) flap reconstruction. Following surgery, she received ten chemotherapy treatments over 5 months. Three months after chemotherapy initiation, she developed a painful, erythematous, vesicular rash along the right side of her abdomen, which extended to the right side of her chest, clearly crossing dermatomal distributions. Disseminated herpes zoster was suspected. However, extensive examination revealed that she had monodermatomal herpes zoster secondary to TRAM flap procedure. A pseudodisseminated rash appearance had been created by nerve realignment. The woman received oral valaciclovir and her eruption resolved. Author comment: "The chemotherapy, as well as the surgery, may have been predisposing immunosuppressive factors." Tuchman M, et al. Monodermatomal herpes zoster in a pseudodisseminated distribution following breast reconstruction surgery. Cutis 81: 71-72, No. 1, Jan 2008 - USA 801104716 1 Reactions 22 Mar 2008 No. 1194 0114-9954/10/1194-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1194 - 22 Mar 2008
Antineoplastics
Monodermatomal herpes zoster following breastreconstruction surgery: case report
A 45-year-old woman, who had recently undergone breastreconstruction surgery, developed monodermatomal herpeszoster during treatment with antineoplastics [specific drugsand dosages not stated].
The woman was diagnosed with new stage III breast cancerand underwent modified radical mastectomy, followed bytransverse rectus abdominis myocutaneous (TRAM) flapreconstruction. Following surgery, she received tenchemotherapy treatments over 5 months. Three months afterchemotherapy initiation, she developed a painful,erythematous, vesicular rash along the right side of herabdomen, which extended to the right side of her chest, clearlycrossing dermatomal distributions. Disseminated herpeszoster was suspected. However, extensive examinationrevealed that she had monodermatomal herpes zostersecondary to TRAM flap procedure. A pseudodisseminatedrash appearance had been created by nerve realignment.
The woman received oral valaciclovir and her eruptionresolved.
Author comment: "The chemotherapy, as well as thesurgery, may have been predisposing immunosuppressivefactors."Tuchman M, et al. Monodermatomal herpes zoster in a pseudodisseminateddistribution following breast reconstruction surgery. Cutis 81: 71-72, No. 1, Jan2008 - USA 801104716
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Reactions 22 Mar 2008 No. 11940114-9954/10/1194-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
