Antineoplastics
1
Reactions 1433 - 5 Jan 2013 S Antineoplastics Eccrine poromatosis: 4 case reports Four patients, 1 woman and 3 men, developed multiple eccrine poromatosis following antineoplastic therapy. A 66-year-old woman with chronic lymphocytic leukaemia and B-cell follicular lymphoma received multiple cycles of chemotherapy with cyclophosphamide, epirubicin, vincristine, mitoxantrone, methotrexate, prednisolone, etoposide and cisplatin [dosages and routes not stated]. She presented with a 5-year history of multiple skin-coloured or reddish papules and nodules on her extremities and trunk [time to reaction onset and duration of therapy before reaction not stated]. Biopsy findings were consistent with a diagnosis of eccrine poromatosis [treatment given and outcome not stated]. A 62-year-old man with malignant fibrous histiocytoma received 4 courses of doxorubicin 135mg alongside 3 courses of ifosfamide 20g and 1 course of ifosfamide 17.5g [routes not stated]. He presented 41 months postchemotherapy, with a reddish nodule on his right heel. The nodule was excised and biopsy findings were histologically consistent with eccrine poroma. He subsequently experienced three further occurrences of eccrine poromas which were also excised. A 59-year-old man with malignant B-cell lymphoma in the brain received 5 courses of methotrexate 5800mg, cyclophosphamide 1200mg, doxorubicin 80mg, vincristine 2.2mg and prednisolone 360mg (MCHOP) [routes not stated] and 2 courses of rituximab once a week for 4 weeks [dosage and route not stated]. Two further courses of M-CHOP and rituximab were subsequently administered due to lymphoma recurrence [dosages and routes not stated]. He presented 6 months after starting chemotherapy with a pedunculated nodule on his right palm. The lesion was surgically removed and diagnosed histologically as eccrine poroma. He re- presented 18 months later, with recurrent eccrine poroma nodules which were also excised. A 72-year-old man with diffuse large B-cell lymphoma received 7 courses of cyclophosphamide 1400mg, doxorubicin 90mg, vincristine 2mg and prednisolone 110mg (CHOP) [routes not stated] and 12 courses of oral etoposide 75 mg/day for 2 weeks once a month. In 2006, 10 years postdiagnosis, he noticed three reddish nodules on his back and right thigh alongside small multiple reddish papules on his trunk and extremities. He did not present until 2010, at which time the pedunculated nodules were removed surgically and diagnosed histopathologically as eccrine poroma. Author comment: "In our four patients, however, all eccrine poromas occurred on non-irradiated skin and all the patients had undergone intensive treatment with polychemotherapy for various types of neoplasms. These facts suggest that the chemotherapeutic reagents may be responsible for the occurrence of the multiple eccrine poromas." Fujii K, et al. Eccrine poromatosis associated with polychemotherapy. Acta Dermato-Venereologica 92: 687-690, No. 6, Oct 2012. Available from: URL: http:/ /dx.doi.org/10.2340/00015555-1279 - Japan 803081417 1 Reactions 5 Jan 2013 No. 1433 0114-9954/10/1433-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1433 - 5 Jan 2013
SAntineoplastics
Eccrine poromatosis: 4 case reportsFour patients, 1 woman and 3 men, developed multiple
eccrine poromatosis following antineoplastic therapy.A 66-year-old woman with chronic lymphocytic leukaemia
and B-cell follicular lymphoma received multiple cycles ofchemotherapy with cyclophosphamide, epirubicin, vincristine,mitoxantrone, methotrexate, prednisolone, etoposide andcisplatin [dosages and routes not stated]. She presented with a5-year history of multiple skin-coloured or reddish papulesand nodules on her extremities and trunk [time to reactiononset and duration of therapy before reaction not stated].Biopsy findings were consistent with a diagnosis of eccrineporomatosis [treatment given and outcome not stated].
A 62-year-old man with malignant fibrous histiocytomareceived 4 courses of doxorubicin 135mg alongside 3 coursesof ifosfamide 20g and 1 course of ifosfamide 17.5g [routes notstated]. He presented 41 months postchemotherapy, with areddish nodule on his right heel. The nodule was excised andbiopsy findings were histologically consistent with eccrineporoma. He subsequently experienced three furtheroccurrences of eccrine poromas which were also excised.
A 59-year-old man with malignant B-cell lymphoma in thebrain received 5 courses of methotrexate 5800mg,cyclophosphamide 1200mg, doxorubicin 80mg, vincristine2.2mg and prednisolone 360mg (MCHOP) [routes not stated]and 2 courses of rituximab once a week for 4 weeks [dosageand route not stated]. Two further courses of M-CHOP andrituximab were subsequently administered due to lymphomarecurrence [dosages and routes not stated]. He presented6 months after starting chemotherapy with a pedunculatednodule on his right palm. The lesion was surgically removedand diagnosed histologically as eccrine poroma. He re-presented 18 months later, with recurrent eccrine poromanodules which were also excised.
A 72-year-old man with diffuse large B-cell lymphomareceived 7 courses of cyclophosphamide 1400mg,doxorubicin 90mg, vincristine 2mg and prednisolone 110mg(CHOP) [routes not stated] and 12 courses of oral etoposide75 mg/day for 2 weeks once a month. In 2006, 10 yearspostdiagnosis, he noticed three reddish nodules on his backand right thigh alongside small multiple reddish papules on histrunk and extremities. He did not present until 2010, at whichtime the pedunculated nodules were removed surgically anddiagnosed histopathologically as eccrine poroma.
Author comment: "In our four patients, however, alleccrine poromas occurred on non-irradiated skin and all thepatients had undergone intensive treatment withpolychemotherapy for various types of neoplasms. These factssuggest that the chemotherapeutic reagents may beresponsible for the occurrence of the multiple eccrineporomas."Fujii K, et al. Eccrine poromatosis associated with polychemotherapy. ActaDermato-Venereologica 92: 687-690, No. 6, Oct 2012. Available from: URL: http://dx.doi.org/10.2340/00015555-1279 - Japan 803081417
1
Reactions 5 Jan 2013 No. 14330114-9954/10/1433-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
