Antineoplastics
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Reactions 1430 - 1 Dec 2012 Antineoplastics Peripheral neuropathy, nausea and fatigue: case report A 57-year-old woman experienced peripheral neuropathy, nausea and fatigue while receiving modified FOLFOX6 therapy (fluorouracil, folinic acid [leucovorin], oxaliplatin) and bevacizumab. The woman underwent sigmoidectomy for advanced sigmoid colon cancer in 2002. She underwent partial liver resection in 2003, following the discovery of metastases. Right adrenal and para-aortic lymph node metastases were discovered in February 2007, and she received six courses of modified FOLFOX6 [dosages and routes not stated]. She experienced grade 1 peripheral neuropathy and grade 2 nausea/vomiting [time to onset not stated]. She subsequently underwent surgery. She was discharged 13 days later, and she received four courses of modified FOLFOX6 as postoperative adjuvant therapy. In September 2008, an accumulation of tumour markers was discovered in the adrenal gland excision area; she started receiving modified FOLFOX6 and bevacizumab 200 mg/m 2 [route not stated]. She experienced grade 2 peripheral neuropathy, grade 1 nausea and grade 1 general fatigue [time to onset not stated]. The woman started a "drug holiday" in February 2009. Modified FOLFOX6 and bevacizumab were restarted after elevated tumour marker levels were discovered in August 2009. No signs of disease recurrence were apparent in images taken in July 2010. Author comment: Chemotherapy was temporarily stopped due to adverse reactions, such as peripheral neuropathy, general fatigue and nausea. Kim HM, et al. A case of recurrent sigmoid colon cancer with adrenal and para- aortic lymph node metastasis successfully treated by operation and chemotherapy. Gan to Kagaku Ryoho 37: 2548-2550, No. 12, Nov 2010 [Japanese; summarised from a translation] - Japan 803080504 1 Reactions 1 Dec 2012 No. 1430 0114-9954/10/1430-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1430 - 1 Dec 2012
Antineoplastics
Peripheral neuropathy, nausea and fatigue: casereport
A 57-year-old woman experienced peripheralneuropathy, nausea and fatigue while receiving modifiedFOLFOX6 therapy (fluorouracil, folinic acid [leucovorin],oxaliplatin) and bevacizumab.
The woman underwent sigmoidectomy for advancedsigmoid colon cancer in 2002. She underwent partial liverresection in 2003, following the discovery of metastases.Right adrenal and para-aortic lymph node metastases werediscovered in February 2007, and she received six coursesof modified FOLFOX6 [dosages and routes not stated]. Sheexperienced grade 1 peripheral neuropathy and grade 2nausea/vomiting [time to onset not stated]. Shesubsequently underwent surgery. She was discharged13 days later, and she received four courses of modifiedFOLFOX6 as postoperative adjuvant therapy. InSeptember 2008, an accumulation of tumour markers wasdiscovered in the adrenal gland excision area; she startedreceiving modified FOLFOX6 and bevacizumab 200 mg/m2
[route not stated]. She experienced grade 2 peripheralneuropathy, grade 1 nausea and grade 1 general fatigue[time to onset not stated].
The woman started a "drug holiday" in February 2009.Modified FOLFOX6 and bevacizumab were restarted afterelevated tumour marker levels were discovered inAugust 2009. No signs of disease recurrence were apparentin images taken in July 2010.
Author comment: Chemotherapy was temporarilystopped due to adverse reactions, such as peripheralneuropathy, general fatigue and nausea.Kim HM, et al. A case of recurrent sigmoid colon cancer with adrenal and para-aortic lymph node metastasis successfully treated by operation and chemotherapy.Gan to Kagaku Ryoho 37: 2548-2550, No. 12, Nov 2010 [Japanese; summarisedfrom a translation] - Japan 803080504
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Reactions 1 Dec 2012 No. 14300114-9954/10/1430-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
