Antineoplastics
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Reactions 1247 - 11 Apr 2009 S Antineoplastics Acute myeloid leukaemia in a child?: case report A 3-year-old boy with atypical teratoid/rhabdoid tumour of the brain, who was conceived using in vitro fertilisation, developed acute myeloid leukaemia after treatment with etoposide, ifosfamide, vincristine, dactinomycin and cyclophosphamide. The boy underwent subtotal removal of a mass around the posterior fossa. Histologically, the mass was consistent with atypical teratoid/rhabdoid tumour. He received induction therapy according to the Intergroup Rhabdomyosarcoma Study protocol including IV ifosfamide (cumulative dose, 54 g/m 2 ), IV etoposide (cumulative dose, 3000 mg/m 2 ), vincristine [dosage not clearly stated], dactinomycin [dosage not clearly stated], IV cyclophosphamide (cumulative dose 12 g/m 2 ), and radiotherapy. Seventeen months after the initial diagnosis, he had a haemoglobin level of 9.3 g/dL, a leukocyte count of 80 300/mm 3 (with 17% blasts, 39% neutrophils, 21% monocytes and 8% lymphocytes) and a platelet count of 51 000/mm 3 [duration of therapy to reaction onset not clearly stated]. Blasts and myelodysplastic features, with positivity for myeloperoxidase staining, were observed in bone marrow aspirate. Positivity for CD13 and CD33 was also found and he had a bone marrow karyotype of 46, XY. The boy had developed secondary or therapy-related M2 acute myeloid leukaemia. He was started on anti-leukaemic therapy. [Patient outcome not stated]. Author comment: "We report a case of atypical teratoid/ rhabdoid tumor (AT/RT) of the brain and acute myeloid leukaemia (AML), secondary or therapy related, in a boy born after IVF." Kim YD, et al. Secondary leukemia in a child conceived using in vitro fertilization. Pediatrics International 50: 831-832, No. 6, Dec 2008 - South Korea 801126571 1 Reactions 11 Apr 2009 No. 1247 0114-9954/10/1247-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1247 - 11 Apr 2009
SAntineoplastics
Acute myeloid leukaemia in a child?: case reportA 3-year-old boy with atypical teratoid/rhabdoid tumour
of the brain, who was conceived using in vitro fertilisation,developed acute myeloid leukaemia after treatment withetoposide, ifosfamide, vincristine, dactinomycin andcyclophosphamide.
The boy underwent subtotal removal of a mass aroundthe posterior fossa. Histologically, the mass was consistentwith atypical teratoid/rhabdoid tumour. He receivedinduction therapy according to the IntergroupRhabdomyosarcoma Study protocol includingIV ifosfamide (cumulative dose, 54 g/m2), IV etoposide(cumulative dose, 3000 mg/m2), vincristine [dosage notclearly stated], dactinomycin [dosage not clearly stated],IV cyclophosphamide (cumulative dose 12 g/m2), andradiotherapy. Seventeen months after the initial diagnosis,he had a haemoglobin level of 9.3 g/dL, a leukocyte count of80 300/mm3 (with 17% blasts, 39% neutrophils, 21%monocytes and 8% lymphocytes) and a platelet count of51 000/mm3 [duration of therapy to reaction onset notclearly stated]. Blasts and myelodysplastic features, withpositivity for myeloperoxidase staining, were observed inbone marrow aspirate. Positivity for CD13 and CD33 wasalso found and he had a bone marrow karyotype of 46, XY.
The boy had developed secondary or therapy-related M2acute myeloid leukaemia. He was started on anti-leukaemictherapy. [Patient outcome not stated].
Author comment: "We report a case of atypical teratoid/rhabdoid tumor (AT/RT) of the brain and acute myeloidleukaemia (AML), secondary or therapy related, in a boy bornafter IVF."Kim YD, et al. Secondary leukemia in a child conceived using in vitro fertilization.Pediatrics International 50: 831-832, No. 6, Dec 2008 - South Korea 801126571
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Reactions 11 Apr 2009 No. 12470114-9954/10/1247-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
