Antineoplastics
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Reactions 1431 - 8 Dec 2012 S Antineoplastics Immunosuppression leading to septic arthritis: case report A 64-year-old woman with non-Hodgkin’s lymphoma (NHL) developed septic arthritis, after experiencing immunosuppression after chemotherapy with cytarabine, bleomycin, vincristine and methotrexate. The woman was admitted for NHL staging with fever and asthenia. After prior NHL diagnosis in January 2010, she had received cytarabine [Aracytin], bleomycin, vincristine and methotrexate [routes, dosages and time to reaction onset not stated]. Chemotherapy had been withdrawn at the second cycle due to decreased white blood cell and haemoglobin levels. At examination, she had pain on pressure over her left hip, with functional impotence and immobilisation in an antalgic position. Her symptoms, taken together with fludeoxyglucose F18-PET/CT scan results, led to suspicion of a septic process in her left hip. Her haemoglobin and white blood cell levels were below the normal ranges, and she had an elevated erythrocyte sedimentation rate and C-reactive protein level. MRI suggested septic arthritis, and blood cultures revealed Escherichia coli. The woman received ciprofloxacin; her fever and hip pain resolved, and after 21 days of treatment her inflammatory indexes normalised. Author comment: The authors report a woman "who showed immunosuppression after chemotherapy, joint pain at the left hip joint, that will result [in] a septic arthritis." Niccoli Asabella A, et al. Different causes of 18-Fluorine- labelled-2-deoxy-2-fluoro-D-glucose uptake in a patient with non-Hodgkin lymphoma. Gazzetta Medica Italiana Archivio per le Scienze Mediche 171: 351-356, No. 3, Jun 2012 - Italy 803080950 1 Reactions 8 Dec 2012 No. 1431 0114-9954/10/1431-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1431 - 8 Dec 2012
SAntineoplastics
Immunosuppression leading to septic arthritis:case report
A 64-year-old woman with non-Hodgkin’s lymphoma(NHL) developed septic arthritis, after experiencingimmunosuppression after chemotherapy with cytarabine,bleomycin, vincristine and methotrexate.
The woman was admitted for NHL staging with fever andasthenia. After prior NHL diagnosis in January 2010, shehad received cytarabine [Aracytin], bleomycin, vincristineand methotrexate [routes, dosages and time to reactiononset not stated]. Chemotherapy had been withdrawn atthe second cycle due to decreased white blood cell andhaemoglobin levels. At examination, she had pain onpressure over her left hip, with functional impotence andimmobilisation in an antalgic position. Her symptoms,taken together with fludeoxyglucose F18-PET/CT scanresults, led to suspicion of a septic process in her left hip.Her haemoglobin and white blood cell levels were belowthe normal ranges, and she had an elevated erythrocytesedimentation rate and C-reactive protein level. MRIsuggested septic arthritis, and blood cultures revealedEscherichia coli.
The woman received ciprofloxacin; her fever and hippain resolved, and after 21 days of treatment herinflammatory indexes normalised.
Author comment: The authors report a woman "whoshowed immunosuppression after chemotherapy, joint painat the left hip joint, that will result [in] a septic arthritis."Niccoli Asabella A, et al. Different causes of 18-Fluorine-labelled-2-deoxy-2-fluoro-D-glucose uptake in a patient with non-Hodgkinlymphoma. Gazzetta Medica Italiana Archivio per le Scienze Mediche 171:351-356, No. 3, Jun 2012 - Italy 803080950
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Reactions 8 Dec 2012 No. 14310114-9954/10/1431-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
