Amlodipine/benazepril
1
Reactions 1093 - 18 Mar 2006 S Amlodipine/benazepril Unilateral tongue angioedema in an elderly patient: case report A 68-year-old woman developed unilateral tongue angioedema during treatment with amlodipine and benazepril for hypertension. The woman presented with a 7-hour history of sudden- onset, slowly progressed, right-sided tongue swelling. Her medications included concomitant amlodipine [Norvasc] 5 mg/day and benazepril 25 mg/day, of several months’ duration, and chlortalidone. Examination showed an asymmetrically enlarged, soft, nontender tongue, with swelling on the right side significantly greater than the left. She had a BP of 166/85mm Hg and a HR of 83 beats/min. She was diagnosed with angioedema and hospitalised. The woman received IV diphenhydramine, methylprednisolone sodium succinate and famotidine and, the next morning, her symptoms had completely resolved. She received a 4-day oral prednisolone course, in addition to further famotidine and diphenhydramine. At 2-months’ follow- up, no further angioedema episodes were reported. Author comment: "She had been taking the calcium channel blocker Norvasc for several months, a drug displaying the dose-dependent side effect of angioedema." Chan Y-F, et al. Angiotensin-converting enzyme inhibitors as a cause of unilateral tongue angioedema in a 68-year-old woman. American Journal of Emergency Medicine 24: 249-250, No. 2, Mar 2006 - USA 801036235 1 Reactions 18 Mar 2006 No. 1093 0114-9954/10/1093-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Amlodipine/benazepril
Reactions 1093 - 18 Mar 2006
SAmlodipine/benazepril
Unilateral tongue angioedema in an elderly patient:case report
A 68-year-old woman developed unilateral tongueangioedema during treatment with amlodipine and benazeprilfor hypertension.
The woman presented with a 7-hour history of sudden-onset, slowly progressed, right-sided tongue swelling. Hermedications included concomitant amlodipine [Norvasc]5 mg/day and benazepril 25 mg/day, of several months’duration, and chlortalidone. Examination showed anasymmetrically enlarged, soft, nontender tongue, withswelling on the right side significantly greater than the left. Shehad a BP of 166/85mm Hg and a HR of 83 beats/min. She wasdiagnosed with angioedema and hospitalised.
The woman received IV diphenhydramine,methylprednisolone sodium succinate and famotidine and, thenext morning, her symptoms had completely resolved. Shereceived a 4-day oral prednisolone course, in addition tofurther famotidine and diphenhydramine. At 2-months’ follow-up, no further angioedema episodes were reported.
Author comment: "She had been taking the calciumchannel blocker Norvasc for several months, a drug displayingthe dose-dependent side effect of angioedema."Chan Y-F, et al. Angiotensin-converting enzyme inhibitors as a cause of unilateraltongue angioedema in a 68-year-old woman. American Journal of EmergencyMedicine 24: 249-250, No. 2, Mar 2006 - USA 801036235
1
Reactions 18 Mar 2006 No. 10930114-9954/10/1093-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
