Reactions 1180 - 1 Dec 2007

SCarbamazepine

EEG abnormalities following massive toxicity: casereport

A 21-year-old man was found comatose with seizures; onday 1, an EEG showed continuous, generalised, rhythmic,high-amplitude delta waves with a frequency of 0.5–1Hz, andhe had massive carbamazepine toxicity with a concentration of71.1 mg/L [dosage, indication and time to reaction onset notstated]. On day 2, EEG showed generalised alpha activity; onday 4, he had continuous slow activity of 1–2Hz, and acarbamazepine concentration of 21.3 mg/L [treatment notstated]. His recovery was uneventful.Ting SKS, et al. Serial EEG findings in massive carbamazepine toxicity. EuropeanJournal of Neurology 14 (Suppl. 1): 92, Aug 2007 [abstract] -Singapore 801084812

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Reactions 1 Dec 2007 No. 11800114-9954/10/1180-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved