Reactions 1387 - 4 Feb 2012

SAntineoplastics

Various toxicities in older patients: 13 casereports

Thirteen men with testicular germ cell cancer receivedantineoplastics including bleomycin, etoposide, cisplatin,cyclophosphamide and carboplatin, and developed variousadverse events [see table 1].

Patient characteristicsPatient/ Chemotherapy Adverse events (gradea)age (y) (no. of cycles)

1/60 BEP (4) thrombocytopaenia (4); sensoryneuropathy (3)

2/66 EP (4) vomiting (2)3/61 carboplatin (4) nausea (1)4/61 CyE (6) vomiting (1)5/68 BEP (4) febrile neutropaenia (3);

hypocalcaemia (2);hypomagnesaemia (2)

6/85 carboplatin (4) nausea (2)7/63 EP (4) febrile neutropaenia (3)8/73 BEP (3) febrile neutropaenia (3);

vomiting (3); tinnitus (2)9/60 BEPb (6) thrombocytopaenia (4);

anaemia (3)10/65 EP (3) then EC (1) febrile neutropaenia (4); elevated

creatinine (2); deep veinthrombosis (3)

11/64 EP (4) febrile neutropaenia (3); sensoryneuropathy (2)

12/71 EPb (4) nausea (2); sensoryneuropathy (1)

13/69 BEP (1) then elevated creatinine (2);EP (1) then EC (2) gastrointestinal bleed (3)

a CTCAE version 3b reduced dose

Treatments included BEP (bleomycin 30 000IU day 2,cisplatin 100 mg/m2, etoposide 500 mg/m2), EP (cisplatin100 mg/m2, etoposide 500 mg/m2), carboplatin (full dose,AUC 5), CyE (oral cyclophosphamide and etoposide), EC(etoposide and carboplatin), and EP (etoposide andcisplatin) [all other routes, dosages and frequencies notstated; treatment durations to onset of reactions andoutcomes not stated].Wheater MJ, et al. The clinical features and management of testicular germ celltumours in patients aged 60 years and older. BJU International 108: 1794-1799,No. 11, Dec 2011. Available from: URL: http://dx.doi.org/10.1111/j.1464-410x.2011.10252.x - United Kingdom 803066442

1

Reactions 4 Feb 2012 No. 13870114-9954/10/1387-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved