Lorem Ipsum Dr. Victor W. Hsu Dr. Todd L. Lowary Dr. Victor W. Hsu
Dr. Todd L. Lowary
THE TAIWANSOCIETY FOR BIOCHEMISTRY ANDMOLECULAR BIOLOGY
p.6-10 102323
p.11-15
[email protected]
p.15 27 & (02)2366-5574
p.16 26 1 http://www.tsbmb.org.tw
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2020
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2020
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… DNARNA DNARNA amino acids UC Davis
Yale University
PI
1988 Michigan State University C Winter break Veronica Maher
Maher Justin McCormick Carcinogenesis Lab Maher mutation spectrum
McCormick Cancer cell immortalization lab meeting journal
club
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Xeroderma pigmentosum (XP) XPAGXP variantXP DNA XP variant Maher
Sup FHPRT Sup FXP variant MaherOh my goodness~ XP variant
DNADNA- polymerase eta translesion synthesis DNA PNAS HPRTMolecular
and Cellular Biology Maher
Maher cut & paste Maher rationale PI Maher negative results
long distance call edit mode
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mismatch repair …
Cancer Genomics & Epigenomics
8
genomics & epigenomics 2006 2010 Journal of Clinical
Investigation NNK DNA
on-line database Ohio State University (Dr. Tim Huang)The
University of Chicago Medical Center (Dr. Ravi Salgia) in-house
cohort
Bioinformatics
Exocytosis & Tumor microenvironment
candidate gene approach ZNF322A zinc finger NRF2
Rab37Rab37 Exocytosis tumor microenvironment Rab (vesicle traffic)
Rab37 (cargos) Rab37 Oh my goodness, to see is to believe
Rab37
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2017 Rab37 Rab37
20153 32 IUBMB Life
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(Ligand- targeted therapy) (Interstitial fluid pressure, IFP)
(Phage display)
2018 (George P. Smith ) (Gregory P. Winter)
(Humanized)
(Affinity Maturation) (KD)10-10 M ~ 10-11 M
Globo HSSEA3SSEA4 hSSEA4Abv3.1 SSEA4
11093 66 2068 7
7 202012 (NAI) 1,403NAI250 42,700
2010
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(Incubator)
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