Robert Malinowski

Going Integrative

ERA Chairs in Europe – Pilot Call

1

1

3

6

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5 VetMedZed 9

TUTIC Green

Re-SIZED

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CEITEC

3

6 7

BIO-TALENT

LEAPFROG

11 MEGABIOVIN Serbia

11

9

7

ERADIATE

ISOFOOD 8

8

4 ECOAQUA

4

10 GRO

10

Re-SIZED

BELGIUM

University de Mons

Energy efficiency in cities

Thermal storage

Low energy consumption

Smart grids

Sustainable transport

Christos IOAKEIMIDIS

CEITEC

CZECH REPUBLIC

Masaryk University

Central European Institute of Technology

Life sciences – RNA and immunity

Research areas

• Identification of novel RNA editing/RNA modification events in RNA

• Investigating the biological function of nucleotide modification in innate immunity

• Elucidating the role RNA modification in disease

Mary O’CONNELL

TUTIC Green

ESTONIA

Tallinn Univeristy of Technology

Chemistry and biomass treatment

Nicholas GATHERGOOD

Ionic liquids

ERA Chairs in Europe – Second Call

Serbia

1

1

1

1

1

1

1

1

1

1

1

2

2

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2 2

2 2

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Poznań

• Largest plant research community in Poland

• Tradition

Plant Blindness

• The inability to see or notice the plants in the environment

[Stefano Mancuso]

INTEGRATIVE SUPPORTS SYSTEM APPROACH

• Integrative biology is the study and research of biological systems. It does not simply involve one discipline, but integrates a wide variety of disciplines that work together to find answers to scientific questions.

• An Integrative Biology approach addresses the biological question(s) by integrating holistic (genome wide; omics-) approaches with in depth functional analysis and computation biology (modeling), thereby integrating wet and dry lab approaches. VIB’s definition of integrative biology

INTEGRATIVE SUPPORTS SYSTEM APPROACH

ALTERATION OF PLANT

ARCHITECTURE

CELL

LEAF

SHOOT FLOWER

ROOT

CELL

•SIZE

•SHAPE

•ORGAN INITIATION

LEAF

•SIZE

•SHAPE

•ANATOMY

•PHYLOTAXY

SHOOT

•GROWTH

•BRANCHING

•GRAVITROPISM

FLOWER

•PATTERN

•SIZE

•SHAPE

•SEX

ROOT

•GROWTH PATTERN

•BRANCHING

•SECONDARY THICKENNING

http://www.psmag.com

Plants as the gateway to understanding our planet

WP2: BRAIN GAIN

WP2 is intended to recruit 6 talented researchers (R3, R2, R1) with excellent skills and the innovation broker (starting his/her job M25), that will form the BIO-TALENT team.

Their recruitment strategy, career development and working conditions will be in line with the European Charter for Researchers and Code of Conduct for the Recruitment of Researchers.

WP2 BRAIN GAIN

COMPOSITION OF THE NEW TEAM

TRANSCRIPTOMICS

BIOINFORMATICS

DEVELOPMENTAL

BIOLOGY

MOLECULAR ENGINEERING

DEVELOPMENTAL BIOLOGY - Robert Malinowski [ERA-Chair Holder] - Karolina Stefanowicz [R2 Junior Postdoc] - Marcin Olszak [SonataBIS2 – research

associate] - Piotr Walerowski [Sonata BIS2 – PhD

student]

TRANSCRIPTOMICS - Jorge Paiva [Senior R3 Researcher]

MOLECULAR ENGINEERING - Franklin Gregory [Senior R3 Researcher] - Preeti Shakya [PhD student]

BIOINFORMATICS - William Truman [R2 Senior Postdoc] REVERSE GENETICS - To be announced

WP3: ENHANCEMENT OF RESEARCH EXCELLENCE

WP3 will assure excellence of research leading to the leverage of research performance of the Institute.

The aim of this WP is to advance scientific discovery and enhance research excellence and to train young researchers.

They speak…

Plants for Future Climate • Pisum sativum reverse genetics for development

modification

Polish Academy of Sciences

Botanical Garden – Center for Biological Diversity Conservation in Powsin Warsaw, Poland

Cell differentiation

Differentiate

Positional

information (auxin,

signals from

adjoining cells,

environmental

cues)

Transcriptional

activation of cell-

specific gene

expression patterns.

Remain

undifferentiated

Communicate with

adjoining cells

http://www.plantcell.org/teachingtools/teaching.dtl

tekst

• Energy (fire, bio-fuels)

• Fibres: paper, timber, textils…

• Bio-molecules (eg. tannins, xylan, gums,beta-glucans )

• Fruit firmness and conservation

• Insulation materials, stoppers

Biologia roślin drzewiastych

Materiały potencjalnie użyteczne dla przemysłu

Główna idea projektu

Novel insights on the molecular regulatory mechanisms underlying:

Poprawa jakości i

ilości biomasy

(eg. Bioenergy,

alimentar fiber, pulp and

paper)

Model species: Salix pupurea

Wtórne przemiany ściany komórkowej

Biosynteza i pozyskanie substancji aktywnych

Bioaktywne sybstancje

(eg. salicylate glucosides,

tanins, etc)

PurpleWalls Sonata bis

(submitted)

BitterPurple Opus 10 (in

preparation)

The case of weird pathogen

E2F/DP/RBR1 complex

Synteza nanocząsteczek w ekstraktach W. somnifera

(A) Color change of Withania somnifera aqueous extract in the presence of AgNO3 after different time periods indicating silver nanoparticle formation. (B) UV-vis spectra of the above solution at 300-700 nm showing absorption maxima at 430 nm confirming the reduction of silver ion to silver metal.

Czynniki decydujące o stopniu powodzenia projektu

1.Znajomość realiów naukowych Polski 2.Przygotowanie instytucji gospodarza 3.Wsparcie jednostek finansujących naukę

Zagrożenia • Brak finansowania na rozpoczęcie działalności

badawczej

• Ważnym aspektem jest zaangażowanie instytucji która otrzymała grant w działalność badawczą gości

• Zielona biotechnologia w Polsce nie istnieje a hodowla roślin podupada – praktyczny brak możliwości współpracy z przemysłem

• Polska krajem wolnym od GMO

• Zrozumienie celu wystąpienia o projekt

• Polska jest w niewielkim stopniu przygotowana na przyjęcie naukowców z poza granicy

-biurokracja

-nieznajomość języka angielskiego