PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol
description
Transcript of PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol
PBS
10 mg/kg paracetamol
50 mg/kg paracetamol
100 mg/kg paracetamol
200 mg/kg paracetamol
PBS
10 mg/kg caffeine
10 mg/kg paracetamol + 10 mg/kg caffeine
50 mg/kg paracetamol + 10 mg/kg caffeine
100 mg/kg paracetamol + 10 mg/kg caffeine
200 mg/kg paracetamol + 10 mg/kg caffeine
PBS
Paracetamol
10 mg/kg caffeine
Paracetamol + 10 mg/kg caffeine
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Dose of paracetamol (mg/kg)
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PBS
50mg/kg paracetamol
3mg/kg SCH58261
50mg/kg paracetamol + 3mg/kg SCH58261
PBS
50mg/kg paracetamol
10mg/kg PSB1115
50mg/kg paracetamol + 10mg/kg PSB1115
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PBS
10 mg/kg paracetamol
20 mg/kg paracetamol
50 mg/kg paracetamol
100 mg/kg paracetamol
200 mg/kg paracetamol
PBS
10 mg/kg caffeine
50 mg/kg paracetamol + 10 mg/kg caffeine
100 mg/kg paracetamol + 10 mg/kg caffeine
200 mg/kg paracetamol + 10 mg/kg caffeine
PBS
Paracetamol
10 mg/kg caffeine
Paracetamol + 10 mg/kg caffeine
Res
pons
e La
tenc
y (s
)R
espo
nse
Late
ncy
(s)
*
*
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**
(B)
0
5
10
15
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-10 15 30 45Time (min)
Res
pons
e La
tenc
y (s
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*
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10
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-10 15 30 45Time (min)
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#
Dose of paracetamol (mg/kg)
0
5
10
15
20
0 10 100 1000
(C)
PBS
50mg/kg paracetamol
3mg/kg SCH58261
50mg/kg paracetamol + 3mg/kg SCH58261
PBS
50mg/kg paracetamol
10mg/kg PSB1115
50mg/kg paracetamol + 10mg/kg PSB1115
0
5
10
15
20
-10 15 30 45time (min)
(A)
0
5
10
15
20
-10 15 30 45time (min)
Res
pons
e La
tenc
y (s
ec)
Res
pons
e La
tenc
y (s
ec)
(B)
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*
#
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