PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol

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PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol PBS 10 mg/kg caffeine 10 mg/kg paracetamol + 10 mg/kg caffeine 50 mg/kg paracetamol + 10 mg/kg caffeine 100 mg/kg paracetamol + 10 mg/kg caffeine 200 mg/kg paracetamol + 10 mg/kg caffeine PBS Paracetamol 10 mg/kg caffeine Paracetamol + 10 mg/kg caffeine 5 Response Latency (s) * 0 1 2 3 4 -10 15 30 45 * * * * * * * * * (A ) Time (min) Time (min) * * (B ) 0 1 2 3 4 5 -10 15 30 45 Response Latency (s) 5 # # # * (C) Dose of paracetamol (mg/kg) 0 1 2 3 4 0 10 100 1000 Response Latency (s)

description

5. (A). *. *. 4. *. *. *. *. *. 3. *. Response Latency (s). *. *. PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol. 2. 1. 0. 15. 30. 45. -10. Time (min). 5. (B). 4. PBS 10 mg/kg caffeine - PowerPoint PPT Presentation

Transcript of PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol

Page 1: PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol

PBS

10 mg/kg paracetamol

50 mg/kg paracetamol

100 mg/kg paracetamol

200 mg/kg paracetamol

PBS

10 mg/kg caffeine

10 mg/kg paracetamol + 10 mg/kg caffeine

50 mg/kg paracetamol + 10 mg/kg caffeine

100 mg/kg paracetamol + 10 mg/kg caffeine

200 mg/kg paracetamol + 10 mg/kg caffeine

PBS

Paracetamol

10 mg/kg caffeine

Paracetamol + 10 mg/kg caffeine

5

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-10 15 30 45

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Time (min)

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Dose of paracetamol (mg/kg)

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Page 2: PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol

PBS

50mg/kg paracetamol

3mg/kg SCH58261

50mg/kg paracetamol + 3mg/kg SCH58261

PBS

50mg/kg paracetamol

10mg/kg PSB1115

50mg/kg paracetamol + 10mg/kg PSB1115

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(A)

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Page 3: PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol

PBS

10 mg/kg paracetamol

20 mg/kg paracetamol

50 mg/kg paracetamol

100 mg/kg paracetamol

200 mg/kg paracetamol

PBS

10 mg/kg caffeine

50 mg/kg paracetamol + 10 mg/kg caffeine

100 mg/kg paracetamol + 10 mg/kg caffeine

200 mg/kg paracetamol + 10 mg/kg caffeine

PBS

Paracetamol

10 mg/kg caffeine

Paracetamol + 10 mg/kg caffeine

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pons

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tenc

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Dose of paracetamol (mg/kg)

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Page 4: PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol

PBS

50mg/kg paracetamol

3mg/kg SCH58261

50mg/kg paracetamol + 3mg/kg SCH58261

PBS

50mg/kg paracetamol

10mg/kg PSB1115

50mg/kg paracetamol + 10mg/kg PSB1115

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5

10

15

20

-10 15 30 45time (min)

(A)

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-10 15 30 45time (min)

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