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Diet of laboratory animals. Signs of deficiency and excess of nutrients. Message 2. M. Makarova, V. Makarov. ABSTRACT

This report analyzes the anthropomet-ric and clinical signs of the availability of the main food substances (protein, fat, carbohy-drates) and vitamins of laboratory animals. It has been shown that the appearance of such initial symptoms as a violation of appetite, a decrease in the amount of food eaten, a re-duction in body weight, a decrease in mobili-ty, a loss in the luster of the coat, a slow-down in growth, and many others make it possible to suspect abnormalities in animal health due to malnutrition. It is at this stage

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that measures should be taken to verify the qualitative and quantitative composition of feed and rations and to eliminate the identi-fied shortcomings. Particular attention is paid to the quality of nutrition of pregnant and lactating animals in order to ensure the birth of full-fledged offspring, as well as to prevent cases of cannibalism of their own young females. Specific manifestations of nutrient deficiency and excess are also pre-sented, recommendations for their preven-tion are given, among which the most im-portant are observance of the rules for stor-age, processing and preparation of feed, temperature and humidity conditions in ani-mal rooms, ensuring sufficient natural or artificial insolation of animals and timely their treatment for diseases. Knowledge of specific signs of disruption of the supply of individual nutrients will allow for a purpose-ful correction of animal nutrition, without allowing the development of severe irre-versible consequences. At the same time, it is extremely important to implement measures to prevent inadequacies and redun-dancies in the nutrition of laboratory animals at all stages of their maintenance and use in experiments.

Doses of vitamins that have acute toxic effects are given. 1. . -

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12.Otto, G.M. Biology and Diseases of Rats / G.M. Otto, C.L. Franklin, Ch.B. Clifford // In: Laboratory Animal Medi-cine. Third edition. Edited by James G. Fox [et al.]. – Academic Press, Elsevier. – 2015. – P. 151-207.

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by M.A. Suckow, K.A. Stevens, R.P. Wil-son. – Academic Press, Elsevier. – 2012. – P. 217-242.

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