John Walker – Martin Montgomery Mitochondria – ATP Synthase.
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Transcript of John Walker – Martin Montgomery Mitochondria – ATP Synthase.
John Walker – Martin Montgomery
Mitochondria – ATP Synthase
In your body the electric motor enzyme ATP Synthase driven by protons – not electrons – catalyses the reaction: ADP + P → ATP
A protons neutralise negatively charged groups on the stator causing it to turn
www.bioc.aecom.yu.edu
A rotating central spindle opens and closes the cavity gaps
allowing ADP and P in and ATP out
http://en.wikipedia.org/wiki/ATP_synthase
Meccano Clockwork Motor
Hornby Metropolitan Londom Subway Engine
ATP synthase (EC 3.6.3.14) is an important enzyme that provides energy for the cell to use through the synthesis of adenosine triphosphate (ATP). ATP is the most commonly used "energy currency" of cells from most organisms. It is formed from adenosine diphosphate (ADP) and inorganic phosphate (Pi), and needs energy.The overall reaction sequence is: ATP synthase + ADP + Pi → ATP Synthase + ATPEnergy is often released in the form of protium or H+, moving down an electrochemical gradient, such as from the lumen into the stroma of chloroplasts or from the inter-membrane space into the matrix in mitochondria.
rotating spindle
opens and closes the cavities
ADP + P
enter
A protons neutralise negatively charged groups on the stator
causing it to turn
ATP ejected
An electric motor
driven by protons
in water !
A protons neutralise negatively charged groups on the stator causing it to turn – this is a real electric motor – driven by protons – NB in aqueous media!!!!
Central rotating spindle opens and
closes the cavities to allow ADP to enter and ATP to escape
ADP and P enter the cavities and combine to form
ATP
ATP ejected
This is a real electric motor – driven by protons (not electrons)
– NB in water !!!!Paul Boyer and John Walker
Balmoos and Dimroth
rotating spindle opens and closes the
cavities
Protons neutralise –vely charged moiety on rotor causing rotor to rotate 30o
ADP + Pi enter cavity
ATP ejected
ATP
Synthase
Paul Boyer
John Walker