Gujq;fs;

capupay;

juk; 12, 13

njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)

fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)

Gujq;fs;

mkpNdh mkpyq;fshyhdit

20 NtWgl;l tifahd mkpNdh mkpyq;fs; Gujq;fspd; cUthf;fspy; gq;F tfpf;fpd;wd.

C,H,O,N kw;Wk; S %yfr; NrHf;ifahff; fhzg;gLk;.

mkpNdh mkpyf; fl;likg;gpy; kj;jpapy; cs;s fhgd; rkr;rPuw;wJ. tpjptpyf;F– glycine

mkpNdh mkpyj;jpd; nghJthd fl;likg;G

xt;nthU mkpNdh mkpyKk; xU Kidapy; mikNdh (NH2) $l;lj;ijAk; kW Kidapy;

fhnghl;iry; (COOH) $l;lj;ijAk; nfhz;bUg;gJld; H mZ kw;Wk; NtWgl;l $l;lq;fisf; Fwpf;Fk; R vDk; FwpaPl;bidAk; jkJ nghJf;fl;likg;gpy; nfhz;bUf;Fk;

Glycine mkpNdh mkpyj;jpy; R=H

R $l;lk; gf;fr; rq;fpyp vdTk; miof;fg;gLk;

Vida $l;lq;fs; ahTk; KJnfYk;G (back bone) vdTk; miof;fg;gLk; mjhtJ NH2,

COOH ,H $l;lq;fs; mkpNdh mkpyk; xd;wpdJ KJnfYk;ghff; fUjg;gLfpd;wd.

mkpNdh mkpyq;fs; xd;Wf;F Nkw;gl;l mikNdh $l;lq;fs;> kw;Wk; fhnghl;iry; $l;lq;fis nfhz;bUf;fyhk;

R my;yJ gf;fr; rq;fpyp nfhz;Ls;s $Wfspd; mbg;gilapy; mkpNdh mkpyq;fs; tifg;gLj;jg;gLfpd;wd.

mikd; $l;lk;

fhnghl;iry; mkpyf;$l;lk;

rkr;rPuw;w fhgd; α fhgd;

R=CH3/H/

juk; 12, 13

njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)

fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)

Kidtw;w mkpNdh mkpyq;fs;

mkpNdh mkpyj;jpy; fhnghl;iry; kw;Wk; mikNdh $l;lq;fs; rk vz;zpf;ifapy; fhzg;gLk;

gf;fr; rq;fpyp (R) Kidtw;wjhf fhzg;gLk;

gf;fr; rq;fpyp ePH ehl;lkw;wJ

Eg- 01.Alanine

02.Valine

03.Leucine

04.Methionine

(Valine)

gf;fr; rq;fpyp Kidthf;fKs;sJ

,jd; gf;fr; rq;fpyp ePH ehl;lKs;sJ

Eg- 01.Serine

02.Threonine

03.Glutamine

04.Tyrosine

(Glutamine)

Vw;wkw;w KidTs;s mkpNdh mkpyq;fs;

juk; 12, 13

njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)

fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)

kpd;Ndw;wk; nfhz;l gf;fr; rq;fpyp

,q;F gf;fr; rq;fpyp vjpNuw;wk; nfhz;ljhff; fhzg;gLk;

Eg- 01.Aspartic acid

02.Glutamic acid

03.Lysine

04.Arginine

05.Histidine

(Glutamic)

20 tifahd mkpNdh mkpyq;fisg; gaz;gLj;jp fyq;fs; 1000 ,w;Fk; Nkw;gl;l Gujq;fis cUthf;fpf;nfhs;fpd;wd

gf;fr; rq;fpypfspd; ngsjPf> ,urhaz ,ay;Gfspd; mbg;gilapy; Fwpj;j mkpNdh mkpyq;fs; jkf;Fwpa jw;rpwg;ghd ,ay;Gfisf; nfhz;bUf;Fk; ,j;jd;ik gy;ngg;iul; rq;fpypapy; mkpNdh mkpyj;jpd; njhopw;ghl;Lg; gq;fspg;gpy; ghjpg;ig Vw;gLj;Jk;

mkpNdh mkpyj;jpy; fhzg;gLk;

mikNdh $l;lk;- fhu / %y; ,ay;igAk;

fhnghl;iry; $l;lk;-mkpy ,ay;igAk; fhz;gpf;Fk;

,jdhy; mkpNdh mkpyq;fs;

juk; 12, 13

njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)

fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)

Nkyjpff;Fwpg;G

ePupy; fiuf;fg;gLk; NghJ mkpy> fhu ,ay;gpidf; fhz;gpf;Fk; ePHf;fiury; xd;wpDs;

Zwitter ion / Dipolar ion epiyapy; fhzg;gLk;

fiury; Nkyjpfkhf mkpyj;jd;ikahFk;NghJ

fiury; Nkyjpfkhf fhuj;jd;ikahFk;

+H+ - H

+

,t;tpay;G fhuzkhf mkpNdh mkpyq;fs; clypy; jhq;fw;fiuryhf njhopw;gl;L PH

rPuhf;fypy; cjTfpd;wd

kdpjdpy; Fwpj;j tPr;rpDs; FUjp> kw;Wk; tpyq;Ffspy; clw;jputq;fspy; PH khw;wj;ij jhq;Fk; njhopiyr; nra;fpd;wd

Peptide (ngg;iul;;) gpizg;G cUthjy;

,uz;L mkpNdh mkpyq;fspilNa xLf;fw;jhf;fj;jpd; %yk; ePH %yf;$W xd;W mfw;wg;gLtjd; tpisthy; cUthFk; gpizg;G ngg;iul; gpizg;G vdg;gLk;

juk; 12, 13

njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)

fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)

Gujq;fs; xt;nthd;Wk; xd;W my;yJ mjw;F Nkw;gl;l gy;ngg;iul; rq;fpypfshy; Mf;fg;gl;lit. gy;ngg;iul; rq;fpyp xt;nthd;Wk; mkpNdh mkpyq;fspd; NrHf;ifahyhdJ

mbg;gilahf 4 NtWgl;l Gujf; fl;likg;Gfs; fhzg;gLfpd;wd. ,it mtw;wpdJ njhopw;ghl;by; gpujhd gq;fspg;ig toq;Ffpd;wd.

NtWgl;l Gujf; fl;likg;Gfs;

Kjyhd fl;likg;G

Jizahd fl;likg;G

Gilahd fl;likg;G

Gilr;rpiw / ehw;Gilf; fl;likg;G

Kjyhd fl;likg;G (Primary Structure)

jdpj;Jtkhd njhlnuhOq;Fila> Neupa> jhdpnahU gy;ngg;iul; rq;fpyp (,q;F mkpNdh mkpyq;fs; Neupa xOq;fpy; xOq;Fg;gLj;jg;gl;bUf;Fk;)

mkpNdh mkpyq;fspd; vz;zpf;ifAk; mtw;wpd; tiffspd; jdpj;Jtkhd njhlnuhOq;Fk; ,q;F mtjdpf;fggLk;.

juk; 12, 13

njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)

fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)

Jizahd fl;likg;G

Kjyhd fl;likg;Gila jdpnahU gy;ngg;iul; rq;fpyp RUsiltjhy; kw;Wk; kbg;giltjhYk; cUthf;fg;gLk; fl;likg;ghFk;

,J ,Utifg;gLk;

RUsp mikg;G α

kbg;Gj;jhs; mikg;G β

,q;F %yf;$w;W Ijurd; gpizg;Gfs;> xl;rprd; kw;Wk; Ijurd; mZf;fSf;F ,ilNa Vw;gLj;jg;gLfpd;wd

mjhtJ xU mkpNdh mkpyj;jpd; fhgidy; $l;lj;jpYs;s xl;rprd; mZtpw;Fk;> kw;wa mkpNdh mkpyj;jpd; iejurd; mZtpy; ,ize;Js;s IjurDf;Fk; ,ilNa Ijurd; gpizg;G cUthFk; ,q;F Ijurd; gpizg;Gf;fs; xOq;fhd ,ilntspfspy; cUthFk; (4 mkpNdh mkpyq;fis mLj;J) (xU mkpNdh mkpyj;jpd; N-H

$l;lk; kw;wa mkpNdh mkpyj;jpd; C=O $l;lk;)

cjhuzk; - nfuhw;wpd;

,q;F jdpnahU gy;ngg;iul; rq;fpyp jl cUtpy; tUk;NghJ rkhe;jukhf my;yJ vjpH rkhe;jukhf mikAk; gFjpfSf;F ,ilapy; fhgd; mZtpy;,ize;Js;s xl;rprd; mZtpw;Fk; iejurd; mZtpy; ,ize;Js;s Ijurd; mZtpw;Fk; ,ilapy; (%yf;$w;W) Ijurd; gpizg;G Vw;gLj;jg;gLk;

cjhuzk; - gl;Lg;Gujk;

juk; 12, 13

njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)

fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)

Gilahd fl;likg;G

jdpnahU Jizahd gy;ngg;iul;L rq;fpyp NkYk; mjpfstpy; tisjy; kw;Wk; kbg;giljYf;F cl;gLk;NghJ jpUk;gy; mile;J neUf;fkhd Nfhs tbtj;ij cUthf;fp Kg;gupkhzf; fl;likg;igg; ngWk; epiyapy; Gilahd fl;likg;G cUthf;fg;gLfpd;wJ.

Kg;gupkhzf; fl;likg;ghdJ gf;fr; rq;fpypapy; cs;s mZf;fSf;fpilNa Vw;gLj;jg;gLk; ehd;F NtWgl;l gpizg;Gfshy; cWjpg;gLj;jg;gLfpd;wJ

01. Ijurd; gpizg;G

02. ,U fe;jf gpizg;G

03. mad; gpizg;G

04. te;jHthy; (Vander Waals) gpizg;Gf;fs; / ePH ehl;lkw;w ,ilj;jhf;fk;.

cjhuzk; - ngUk;ghyhd nehjpaq;fs;> kNahFNshgpd;> my;Gkpd;

ehw;Gilf; fl;likg;G

,uz;L my;yJ mjw;F Nkw;gl;l gy;ngg;iul;L rq;fpypfs; jpuz;L cUthFk; fl;likg;G

,jpYs;s xt;nthU gy;ngg;iul;L rq;fpypAk; Guj cg myF (Protein Sub Units) vdg;gLk;. ,r; rq;fpypfs; xd;Wld; xd;W %yf;$W mf kw;Wk; %yf;$w;W ,il gpizg;Gfshy; gpizf;fg;gl;bUf;Fk;.

cjhuzk; - nfhyh[d;

juk; 12, 13

njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)

fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)

Gujq;fspd; fl;likg;Gf;fs;

juk; 12, 13

njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)

fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)

,jpy; 3 xj;j RUspAUthd gy;ngg;iul; rq;fpypfs; (α helix)

xl;rprd; ,izAk; Gujk;

,q;F 4 polypeptide rq;fpypfs; fhzg;gLfpd;wd.

2 rq;fpypfs; α tif

2 rq;fpypfs; β tif

xt;nthU rq;fpypAk; Gujkw;w gFjpiaAk; nfhz;bUf;Fk; ,J (Haem) gFjp vdg;gLk; ,Uk;igf; nfhz;lJ.

ehHg;Gujk;

Collagen

juk; 12, 13

njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)

fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)

Gujq;fspd; mikg;gopjy;

Denaturation of protein

Guj %yf;$W xd;wpy; fhzg;gLk; typik Fiwe;j ,urhazg; gpizg;GfSk; kw;Wk;

mtw;Wf;fpilNaahd ,ilj;jhf;fq;fSk; nraypoe;J Nghtjhy; GujkhdJ jdJ

jdpj;Jtkhd ,urhaz Kg;gupkhd fl;likg;ig ,oj;jy; - mikg;gopjy; vdg;gLk;.

mikg;gopjiy Vw;gLj;Jk; fhuzpfs;

caH ntg;gepiyAk; caH fjpupaf;fr; rf;jpAk;

typikahd mkpyq;fs;> td; fhuq;fs; kw;Wk; kpif cg;Gr; nrupTs;s fiury;fs;

ghu cNyhfq;fs;

Nrjdf; fiug;ghd;fs; kw;Wk; ryitg; nghUl;fs; Nghd;wtw;why; gpizg;Gf;fs; ePf;fg;glyhk;

Note - mkpNdh mkpyq;fspd; njhlnuhOq;Nf Gujj;jpd; tbtj;ij jPHkhdpf;Fk;. vdNt

Gujj;jpd; Kjyhd fl;likg;Ng Gujj;jpd; tbtj;ij epHzapf;fpd;wJ. Kjyhd fl;likg;gpy;

xOq;FgLj;jg;gLk; mkpNdh mkpyq;fspd; xOq;FKiwf;Nfw;gNt Gujj;jpy; Ijurd;> ,U

ry;igl;L> kw;Wk; eype;j gpizg;Gf;fs; Vw;gLj;jg;gLfpd;wd.

midj;J Gujq;fspYk; Kjyhd fl;likg;G fhzg;gLk;.

rhjhuz Gujk; mikg;gope;j Gujk;

juk; 12, 13

njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)

fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)

Gujtif cjhuzk; njhopy;fs;

1 Cf;fp Gujk; Pepsin, Amylase capH ,urhaz jhf;fq;fis Cf;Ftpf;Fk;

2 fl;likg;G Gujk; nfuhw;wpd; Collagen cyHjiy jLf;Fk;>cWjp> Mjhuk; toq;Fk;

3 Nrkpg;G Gujk; Kl;il my;Gkpd;> Nfrpd; Kl;ilapy; Nrkpg;G Gujk;> ghypy; Nrkpg;G Gujk;

4 nfhz;L nry;yy; Gujk; rPuk; my;Gkpd;

O2, CO2 flj;jy;> nfhOg;gkpyq;fisf; flj;jy;

5 XNkhd; ,d;Rypd;>FSf;Nfhfd; FUjpapy; FSNfhR kl;lk; rPuhf;fg;gly;

6 RUf;Fk;/,aq;Fk; Gujk; Actin my;yJ Myosin jirehH RUf;fj;ij Vw;gLj;jy;

7 ghJfhg;G Gujk; Immuno globins gpwnghUl;fis mfw;Wjy;

Gujq;fspd; njhopy;fs;

juk; 12, 13

njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)

fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)

caHntg;gepiyfspy; Guj %yf;$Wfs; milAk; khw;wq;fs; mtw;wpw;Fupa fhuzq;fs;

ehshe;j tho;f;ifKiw nraw;ghLfs;> caH mkpy> fhur; nrwpTfspy; Nkw;gb

tpisTfs;> caH fjpHtPr;R nraw;ghL / epiyikfspy; Nkw;gb tpisTfs; ciw

epiyikfspy; (mjpFspH) Nkw;gb tpisTfs; njhlHghf jfty; Nrfupj;J - jfty;

jpul;Lg; Gj;jfk; xd;iw jahupf;fTk;

Assignment

01