11

Centre of Excellence in Bio-safety and Molecular Centre of Excellence in Bio-safety and Molecular Biomedicine - „BioMoBiL”Biomedicine - „BioMoBiL”

Sixth Meeting of the Working Package WP7Sixth Meeting of the Working Package WP7„Final Report and What Did We Achieve ?”„Final Report and What Did We Achieve ?”

Gdańsk, 29 June 2006Gdańsk, 29 June 2006Department of Biology and Pharmaceutical Botany, Faculty of Department of Biology and Pharmaceutical Botany, Faculty of

Pharmacy, MUGPharmacy, MUG

Coordination Office:Coordination Office:

Andrzej C. SkładanowskiAndrzej C. Składanowski

Ewa KiszkaEwa Kiszka

22

33

Research focus of BioMoBiL - Research focus of BioMoBiL - applicationsapplications

Chromosomal Chromosomal genotyping,genotyping,

Molecular markers for Molecular markers for cancer diseasescancer diseases

Molecular diagnostics Molecular diagnostics for invasive diseases,for invasive diseases,

Composed polyvalent Composed polyvalent vaccines vaccines (salmonellosis)(salmonellosis)

Recombinant vaccines Recombinant vaccines for animal viral for animal viral diseases etc.diseases etc.

Molecular markers for Molecular markers for detection of plant detection of plant pathogenic bacteria,pathogenic bacteria,

Biological tests for Biological tests for detection of mutagenic detection of mutagenic polution of marine polution of marine environmentenvironment,,

New photosensitizers in New photosensitizers in photodynamic therapy of photodynamic therapy of cancer,cancer,

Pharmacologically active Pharmacologically active plant secondary plant secondary metabolitesmetabolites

44

Research focus of Research focus of BioMoBiL – basic BioMoBiL – basic sciencessciences Novel mechanisms of DNA replication Novel mechanisms of DNA replication

regulation,regulation, Molecular chaperones in organization Molecular chaperones in organization

and function of nucleoids,and function of nucleoids, Genetic polymorphism and Genetic polymorphism and

conservation of biodiversity of medicinal conservation of biodiversity of medicinal plants, carnivorous plants, orchids, plants, carnivorous plants, orchids, limnofauna and vertebrateslimnofauna and vertebrates

55

Summary of activities Summary of activities in a pillin a pillApril 2003 – June 2006 (3.25 yrs)April 2003 – June 2006 (3.25 yrs)

102 visitors in the Centre (expected 34 more for the Summer School + 10 102 visitors in the Centre (expected 34 more for the Summer School + 10 International Advisory Board)International Advisory Board) 137 Centre members visited abroad137 Centre members visited abroad 66 domestic visits66 domestic visits 3 + 1 Summer Schools of Biotechnology (2003, 2004, 2005, expected 2006)3 + 1 Summer Schools of Biotechnology (2003, 2004, 2005, expected 2006) 2 + 1 Centre Conferences with IAB Meetings (Taylor Conference 2003, 2nd 2 + 1 Centre Conferences with IAB Meetings (Taylor Conference 2003, 2nd

BioMoBiL Conference 2005, expected 3rd Conference in 2006)BioMoBiL Conference 2005, expected 3rd Conference in 2006) 3 other conferences (Scan-Balt Conference 2003, International Student3 other conferences (Scan-Balt Conference 2003, International Student

Scientific Conference 2004, European Workshops on the Molecular Biology ofScientific Conference 2004, European Workshops on the Molecular Biology of

Cyanobacteria, 2005)Cyanobacteria, 2005) 2 + 1 Workshops about intellectual property protection (expected 1 at BSS) ,2 + 1 Workshops about intellectual property protection (expected 1 at BSS) , 2 Established IP data bases (herbal plants, cell lines) and Eucaryotic Cell2 Established IP data bases (herbal plants, cell lines) and Eucaryotic Cell

BankBank Established website: databases with equipment, services, methods, booksEstablished website: databases with equipment, services, methods, books

and materials available in the Centre, visibility in the Internetand materials available in the Centre, visibility in the Internet

66

Mobility - number of visitsMobility - number of visits

WPWP VRVR V1, V2V1, V2

1 (Centre Conferences)1 (Centre Conferences) -- 99

2 (Summer schools)2 (Summer schools) 55 3535

3 (Twinning)3 (Twinning) 2424 11

4 (Networking)4 (Networking) 88 1515

5 (Capacity building)5 (Capacity building) 88 44

6 (Collections, Data 6 (Collections, Data Bases)Bases)

55 11

7 (Laboratory 7 (Laboratory Techniques)Techniques)

7272 2727

8 (Commercialization)8 (Commercialization) 11 --

9 (Coordination)9 (Coordination) 77 66

77

Mobility – countriesMobility – countriesCountryCountry VRVR V1 + V2V1 + V2

GermanyGermany 1515 1717

ItalyItaly 77 88

FranceFrance 55 33

NetherlandsNetherlands 88 66

BelgiumBelgium 55 22

United KingdomUnited Kingdom 1313 77

SpainSpain 55 11

PortugalPortugal 11 11

AustriaAustria 11 --

NAS excl. PolandNAS excl. Poland 55 88

PolandPoland 4242 --

SwedenSweden 1111 33

NorwayNorway 55 --

IrelandIreland 22 --

SwitzerlandSwitzerland 11 11

DenmarkDenmark 22 --

FinlandFinland 1313 55

Czech RepublicCzech Republic -- 22

MacedoniaMacedonia -- 11

USA/CanadaUSA/Canada 33 --

88

Mobility – visiting and revisitingMobility – visiting and revisitingWPWP Both way visits (VR + V1/V2)Both way visits (VR + V1/V2)

11 --

22 --

33 Turku, FinlandTurku, Finland

44 Muenster, Ibbenbueren, Germany Muenster, Ibbenbueren, Germany

55 --

66 --

77 Leuven - BelgiumLeuven - Belgium

Leiden, Wageningen - The NetherlandsLeiden, Wageningen - The Netherlands

Perugia, Ancona - ItalyPerugia, Ancona - Italy

Shiefield, London – UKShiefield, London – UK

Lisbon – PortugalLisbon – Portugal

Umea, Uppsala - SwedenUmea, Uppsala - Sweden

88 --

99 --

99

Summer Schools of Biotechnology, Summer Schools of Biotechnology, Sobieszewo and LapinoSobieszewo and LapinoTopics 2003-2004:Topics 2003-2004:

1.1. Plant biotechnology.Plant biotechnology.2.2. Molecular diagnostics of viral and neoplastic disease.Molecular diagnostics of viral and neoplastic disease.3.3. Bioinformatics – molecular evolution and protein Bioinformatics – molecular evolution and protein

structure.structure.4.4. Genomics, microarrays, molecular diagnosis of cancer.Genomics, microarrays, molecular diagnosis of cancer.5.5. Biotechnological applications in agriculture.Biotechnological applications in agriculture.6.6. White, green and red biotechnology.White, green and red biotechnology.

Topics 2005:Topics 2005:1.1. Proteomics.Proteomics.2.2. Molecular components of transducing pathways.Molecular components of transducing pathways.3.3. Bio-process engineering.Bio-process engineering.

Topics 2006 (expected):Topics 2006 (expected):1.1. Molecular diagnostics of infectious diseases.Molecular diagnostics of infectious diseases.2.2. Molecular diagnostics of cancer diseases.Molecular diagnostics of cancer diseases.3.3. Immunotherapy of cancer.Immunotherapy of cancer.4.4. Stem cells.Stem cells.5.5. Intelectual propoerty rights.Intelectual propoerty rights.

LecturesSeminarsWorkshops

CDs

BioMoBiL Library

S T U D E N T S

1010

Infrastructure available Infrastructure available in the Centrein the Centre

Multi-media projector + laptopMulti-media projector + laptop

Data base system for herbarium and other Data base system for herbarium and other

collectionscollections

Cell & Tissue Bank, deep freezers, RT-PCR Cell & Tissue Bank, deep freezers, RT-PCR

equipmentequipment

BioMoBiL Library, ca. 50 books, BioMoBiL Library, ca. 50 books,

4CDs (Summer Schools lectures and books listed 4CDs (Summer Schools lectures and books listed

on www)on www)

1111

Eucaryotic Cell Banking – Eucaryotic Cell Banking – IRC Success StoryIRC Success Story

http://www.innovationrelay.net/content_db/cddb.cfm?action=article&publication_id=3064&is_article=1&appId=3

1212

Achievements of BioMoBiL Achievements of BioMoBiL compared to other Centres of compared to other Centres of Excellence NAS2Excellence NAS2

http://www.6pr.pl/pliki/4401/2katalog%20LIFE.pdf

http://www.6pr.pl/pliki/4400/1slowo%20wstepne.pdf

1313

Cost summary – 3.5 yearsCost summary – 3.5 years

1st year1st year 118 230, 88 Euro118 230, 88 Euro

2nd year2nd year 102 994, 07 Euro102 994, 07 Euro

3rd year3rd year 97 347, 49 97 347, 49 EuroEuro

4th year - spent mths 37-39 4th year - spent mths 37-39 ca. 30 000 Euroca. 30 000 Euro

- engaged for mths 40-42- engaged for mths 40-42 ca. 30 000 Euroca. 30 000 Euro

- - engaged for BSS, IAB ca. 30 000 Euro

______________________________________________

Planned summary spending: 408 572, 24 Euro

(ca 94 % of total)

Total contracted sum: 434 200 Euro

1414

What for the What for the future ?future ?

1515

ScanBalt ScanBalt - BioMoBiL- BioMoBiLMolecular DiagnosticsMolecular DiagnosticsKnowledge CentreKnowledge Centre

Coordinated by the Coordinated by the Intercollegiate Faculty of BiotechnologyIntercollegiate Faculty of BiotechnologyUniversity of GdaUniversity of Gdańńsk & Medical University of Gdask & Medical University of Gdańńsksk

1616

Micrometastasis Diagnostics:Prof. Klaus Pantel, Hamburg;

Dr. Björn Naume, Oslo

Department of

Biotechnology

IFB UG-MUGMolecular

Diagnostics Division

Prof. Fabien Zoulim, Dr Lycyna CovaINSERM U271, Lyon France

Prof. Burkhard BrandtUniversity Medical CenterCenter of Experimental MedicineInstitute for Tumour BiologyHamburg, Germany

Dr Guy Vernet Emerging Pathogens R&D Dept. bioMerieux, Lyon, France

Prof. Torkel WadströmSection of Med. MicrobiologyDept. of Laboratory MedicineLund University, Sweden

Oncology diagnostics

Diagnostics of infectious diseases

viRgil - Network of Excellence

ScanBaltBioMoBiL

Dr Ulf VogtInstitute of Molecular OncologyEuropean Laboratory AssociationIbbenbueren, Germany (private lab)

H U BH U B

1717

Prof. Hans-Joachim Rziha, Inst. for Animal Health, Tubingen,

GermanyProf. Hans Nauwynck,

University of Ghent, Belgium Intercollegiate Faculty of

Biotechnology

UG-MUG

Dr. Jan van der VolfPRI, Wageningen, The Netherlands

Prof. Thomas Bergstrom, University of Goteborg, Sweden

Prof. Emmanuel Wiertz, University of Leiden, Holland

Dr Ian Barker, CSL, York, Great Britain

Prof. Gunter Adam, University of Hamburg BRD, Germany

Diagnostics of human & animal viral diseases

Diagnostics of plant pathogens

BioMoBiLScanBalt

Prof. Arvind Patel, MRC, Glasgow, Scotland

H U BH U B