CHEMISTRY TEACHING PROGRAM DEPARTMENT MEDICAL CHEMISTRY

Department of Medical Chemistry http://www.ams.edu.pl/wydzialy/wydzial-lekarski/katedra-biochemii-i-chemii-medycznej/zaklad-chemii-medycznej chemia@sci.pam.szczecin.pl Al. Powstańców Wielkopolskich 72 70-111 Szczecin Tel. 0-91 466 16 44 Fax. 0-91 466 16 41 Chief of the department: dr hab. n.med. Joanna Bober Instructor: dr Dobroslawa Stankowska-Walczak Number of hours per subject: 11 hours of lectures 11 hours of seminars 23 hours of laboratories Total number of hours: 45 ECTS: 5

The purpose of teaching medicinal chemistry is to prepare students for learning and understanding of metabolism processes provided during their course of medical study. Students are learning fundamental knowledge of bioinorganic, bioorganic, physical and analytical chemistry. Also, interaction between structure, chemical properties and function of compounds to be found in living organisms are provided. Teaching starts with overview of chemical bonds stabilizing chemical structures. Then, there are widely discussed properties of water and solutions, as a dominated component of human body. Particular impact in students’ teaching is on fundamental, also computational bases of aqueous-electrolytic and acid-base rules. Students also learn about chemical compositions and selected properties of saliva. Remaining problems of bioinorganic chemistry are related to mineral analysis of human organism, with exceptional consideration of micro or trace elements’ properties which are either necessary or toxic for living organisms. Introducing main problems of bioinorganic chemistry is based on teaching fundamental groups of compounds being elemental structure of living organisms such as proteins, lipids, carbohydrates and nucleic acids. Particular impact is on teaching conformation of compounds, which understanding helps analysis of biological results. In course of teaching process, students also learn basis of chemical laboratory work and selected parts of quantitative, qualitative and instrumental analysis of organic and inorganic compounds. The last goal is students’ learning about basic dental material science, chemical structure and reactivity of the compounds applied in dentistry.

FORMS OF TEACHING ACTIVITIES

Chemistry is taught in term II in the amount of 45 hours, in form of lectures, seminars, laboratory classes and tests.

1. There are 11 hours of chemistry lectures during the summer term.

2. There are 11 hours of chemical seminars in IInd semester. They are carried out in 24-

30 students’ group with one teaching assistant and they last in two 45 minutes classes. They are consisting of theoretical introduction to be given by teaching assistant supported with computer animated help.

3. Chemistry laboratory classes are carried out in 23 hours in IInd semester. Laboratories

are in 12-15 students per teaching instructor. Classes last 2 hours. Students are performing their chemical experiments which are directly related to precede theoretical introduction. Results are discussed with instructor after experimental part is completed.

4. The scope of chemistry classes is verified in form of three tests. Tests are carried out

in writing in multiple choice test and they cover materials from lectures, classes and seminars.

LECTURES

1. Water in human organism, Chemistry of saliva. Chemical composition and buffer properties. Structure and properties of water. Influance of dissolced substances on solution properties. Diffusion and osmosis. Osmoticity and tonicity os the soolutions. Donnan’s equilibrium.

2. Chemical bonds in organic compounds. Coordinate bond. Complex compounds – their structure, kind and appearance in nature, application in medical science. Coordination chemistry of bioinorganic compounds, biomolecules containing metals. Metal indicators. Chemical bonds in organic compounds.

3. Role of molecules in biological system. Inorganic components in human organism. Specificity role of trace elements. Metalic ions in biological system. Metailc ions and enzymatic activity. Ultratrace molecules.

4. Lipids. Classification. Saturated and unsaturated fatty acids, structure, nomenclature and properties. Structure and properties of triglycerols. Complex lipids. Chemistry of steran. Structure and physicochemical properties of cholesterol, choalic acid and gallic acid.

5. Polymers. Types of polymerization. Copolymers. Initiators of polymer reactions. Thermoplasts. Duroplasts. Selected examples of polymers.

6. Chemistry of free radicals. Free radicals formation. Reactive forms of oxygen. Nitrate oxide and pernitrates. Organic free radicals. Inactivation of free radicals. Destractive and positive effect of free radicals on building blocks of cells. Positive role of free radicals in human organism. Antioxidative systems and substances.

.

CHEMISTRY SYLLABUS - SEMINARS

1. Acid-base equilibrium. Hydrogen ion concentration, discussion of pH. Henderson–

Hasselbach equation. Buffer capacity. Buffers solution in open and isolated system.

2. Role of water in human body. Structure and chemical properties of water. Influence of substances in solution. Diffusion and osmosis. Osmotic and tonicity of solution. Definition and properties of colloidal system. Classification of colloids. Characteristic of hydrophilic and hydrophobic colloids. Structure of colloids’ micelles. Coagulation and peptization. Donnan’s equilibrium.

3. Characteristic of chemical reaction. Thermodynamic and kinetic probability of reaction. Endothermic and exothermic type of reaction. Energy activation. Open and close systems. Kinethics of chemical reaction. Order and molecularity of reaction. Temperature influence on flow of the reaction.Chemical catalysis.

4. Aminoacids. Structure and classification of aminoacids. Physicochemical properties of aminoacids. Peptide bonds. Structure of proteins. Chemical properties of proteins.Nonprotein aminoacids. Protein structure. and modification.

5. Instrumental methods in biochemical analysis. Absorption laws. Molecular spectroscopy. Absorption and emission atom spectroscopy. Classification of chromatography methods. Principles of mixture separation by adsorption, ion exchange, partition, gel, and affinity chromatography methods. High performance liquid chromatography. Gas chromatography

6. Carbohydrates. Classification of carbohydrates. Chemical and physicochemical properties of monosaccharide (reduction properties, influence of strong acids, enolization, osazone creation). Types of monosaccharide’s isomer (structural and optical isomers, D and L configurations, epimerism, anomerism, pyranoses and furanoses type of rings). Polysaccharides as structural and supply materials – structure and physicochemical properties. Saccharose derivatives with biological meanings: glycosides, hemoglycans and heteroglycanes.

7. Introduction to dentistry material science – Part I. Polymeric materials used in dentistry. Plastic materials used in protetics. Polymeric composites. Polymer matrix. Polymers shrinkage phenomena. Branched polymers. Vinyl and acrylic polymers.

8. Introduction to dentistry material science – Part II. Glass-ionomeric cements – classification, requirements, advantages and disadvanteges. Waxes – structure, classification, properties, application, advantages and disadvantages. Gipsum – classification, properteis and application.

The rules and regulations of chemistry classes

General information 1. Students are working in groups of 12-15 persons with 1 teaching assistant.

2. Groups are formed according to Dean’s Office list.

3. Classes comprises of 11 hours of seminars, l1 hours of lectures and 23 hours of laboratory

classes.

4. Each laboratory session covers theoretical material repetition and experimental part.

5. All the classes are obligatory.

The monitoring of students’ results

1. During the semester there are three written tests. Each test contains 25 questions from lectures, seminars and laboratory. Each question has a value of one point.

2. To get a credit, student has to obtain at least 60% of maximum number of points from each test, which is graded. Laboratory sessions are also graded. Depends on class activities student can get 1-3 points. Maximum collected number of points is 100. 3. Participation in all type of classes is mandatory.

Corrective credits 1. The justified absence from classes has to be made up (in written or oral form) within two

weeks from the absence. If absence is caused by illness or lasts longer then 2 classes, making up for classes will be organized individually.

2. In case of not obtaining required number of points, student has a right to repeat two

corrective credits. 3. Corrective credits are not obligatory. 4. First corrective credit will be performed a week after classes will be finished. 5. Second corrective credit will be performed in the re-sit examination session (September). 6. Subject matter of corrective credit will comprise knowledge from failed test(s). 50 questions to be answered in written form. 7. To get a credit, student has to obtain at least 60% of maximum amount of points from the retake test plus has to confirm attendance during all obligatory activities. Mandatory literature:

1. Laboratory manual for chemistry, Joanna Bober, Barbara Dołęgowska, Dobrosława Stańkowska Walczak. Wyd. PAM. 2010

2. Chemistry, Matters and its changes, James E. Brady, Fred Senese, Wiley 2004 3. Harper’s Biochemistry, Murray K. Robert, Granner K. Daryl, Mayes A. Peter,

Rodwell W. Victor, Appleton and Lange, 2006