Carbamazepine
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Reactions 705 - 13 Jun 1998 Carbamazepine Hypersensitivity with a cutaneous pseudolymphoma: case report A 44-year-old woman developed carbamazepine-induced hypersensitivity, resulting in an eruption with features of a cutaneous, CD30+ pseudolymphoma. The patient, who was allergic to phenytoin, had been treated with carbamazepine [dosage not stated] for 1 month for a seizure disorder. She then developed a morbilliform eruption on her trunk and extremities, dyspnoea, dry cough, fever and myalgias. She had erythematous tympanic membranes, crackles in the base of her lungs and hepatomegaly. A chest x- ray showed bilateral interstitial pneumonitis. Laboratory studies showed elevated liver function tests and leucocytosis. A skin biopsy revealed a superficial and mid-dermal mononuclear infiltrate. Atypical lymphocytes were scattered throughout the dermis and epidermis. These cells were CD3+ and CD30+ lymphocytes. Anticonvulsant hypersensitivity syndrome due to carbamazepine was diagnosed. Carbamazepine was discontinued and her adverse reaction resolved within 3 weeks. Her seizures were subsequently treated with clorazepate and she did not have any further problems during 1 year of follow-up. Nathan DL, et al. Carbamazepine-induced pseudolymphoma with CD-30 positive cells. Journal of the American Academy of Dermatology 38: 806-809, Part 2, May 1998 - USA 800677866 1 Reactions 13 Jun 1998 No. 705 0114-9954/10/0705-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Carbamazepine
Reactions 705 - 13 Jun 1998
Carbamazepine
Hypersensitivity with a cutaneouspseudolymphoma: case report
A 44-year-old woman developed carbamazepine-inducedhypersensitivity, resulting in an eruption with features of acutaneous, CD30+ pseudolymphoma.
The patient, who was allergic to phenytoin, had been treatedwith carbamazepine [dosage not stated] for 1 month for aseizure disorder. She then developed a morbilliform eruptionon her trunk and extremities, dyspnoea, dry cough, fever andmyalgias. She had erythematous tympanic membranes,crackles in the base of her lungs and hepatomegaly. A chest x-ray showed bilateral interstitial pneumonitis. Laboratorystudies showed elevated liver function tests and leucocytosis.A skin biopsy revealed a superficial and mid-dermalmononuclear infiltrate. Atypical lymphocytes were scatteredthroughout the dermis and epidermis. These cells were CD3+and CD30+ lymphocytes.
Anticonvulsant hypersensitivity syndrome due tocarbamazepine was diagnosed. Carbamazepine wasdiscontinued and her adverse reaction resolved within 3weeks. Her seizures were subsequently treated withclorazepate and she did not have any further problems during1 year of follow-up.Nathan DL, et al. Carbamazepine-induced pseudolymphoma with CD-30 positivecells. Journal of the American Academy of Dermatology 38: 806-809, Part 2, May1998 - USA 800677866
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Reactions 13 Jun 1998 No. 7050114-9954/10/0705-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
