Benzodiazepines
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Reactions 408 - 4 Jul 1992 Benzodiazepines Adverse effects in neonates following in utero exposure: clinical study Perinatal complications, low birth weight, and reduced neurological status are more likely to occur in infants born to mothers who have taken benzodiazepines throughout pregnancy. This was the conclusion of a Swedish study which involved 15 mothers who had taken oxazepam 15-60 mg/day or diazepam 5-30 mg/day, alone or in combination, and 1 who had taken lorazepam 5-15 mg/day (total of 17 neonates; ’benzodiazepine’ group). 21 mothers (21 neonates; ’drug’ group) had taken other psychotropic medications. 29 neonates of mothers with no history of drug ingestion formed a control group. In the benzodiazepine and drug groups, intrauterine asphyxia, instrumental delivery, respiratory disturbances, and the need for infection screens, were more common, and overall neurological assessment was worse, compared with controls. Infants were shorter, had a lower birth weight, and had a smaller head circumference in the benzodiazepine group, compared with both of the other groups. Author comment:This appears to be the first study to assess the short term risks of benzodiazepine therapy in mothers who used benzodiazepines as the only prescribed drug in pregnancy, and who did not abuse street drugs or alcohol Laegreid L, et al. The effect of benzodiazepines on the fetus and the newborn. Neuropediatrics 23: 18-23, Feb 1992 - Sweden 800138314 1 Reactions 4 Jul 1992 No. 408 0114-9954/10/0408-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Benzodiazepines
Reactions 408 - 4 Jul 1992
Benzodiazepines
Adverse effects in neonates following in uteroexposure: clinical study
Perinatal complications, low birth weight, and reducedneurological status are more likely to occur in infants born tomothers who have taken benzodiazepines throughoutpregnancy.
This was the conclusion of a Swedish study which involved15 mothers who had taken oxazepam 15-60 mg/day ordiazepam 5-30 mg/day, alone or in combination, and 1 whohad taken lorazepam 5-15 mg/day (total of 17 neonates;’benzodiazepine’ group). 21 mothers (21 neonates; ’drug’group) had taken other psychotropic medications. 29 neonatesof mothers with no history of drug ingestion formed a controlgroup.
In the benzodiazepine and drug groups, intrauterineasphyxia, instrumental delivery, respiratory disturbances, andthe need for infection screens, were more common, andoverall neurological assessment was worse, compared withcontrols.
Infants were shorter, had a lower birth weight, and had asmaller head circumference in the benzodiazepine group,compared with both of the other groups.
Author comment:This appears to be the first study to assessthe short term risks of benzodiazepine therapy in mothers whoused benzodiazepines as the only prescribed drug inpregnancy, and who did not abuse street drugs or alcoholLaegreid L, et al. The effect of benzodiazepines on the fetus and the newborn.Neuropediatrics 23: 18-23, Feb 1992 - Sweden 800138314
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Reactions 4 Jul 1992 No. 4080114-9954/10/0408-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
