Antineoplastics
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Reactions 472 - 9 Oct 1993 Antineoplastics Pericarditis associated with acral erythema: case report A 19-year-old woman with Hodgkin’s disease in relapse experienced acral erythema in association with an asymptomatic pericardial friction rub, following administration of etoposide 60mg/kg and cyclophosphamide 100mg/kg, after autologous bone marrow transplantation. The patient had received preparative, fractionated total body irradiation. Five days after initiation of etoposide and cyclophosphamide, she experienced substernal pleuritic chest pain, which lasted for several days. Swelling of the palms, metacarpophalangeal and interphalangeal joints, a maculopapular eruption over the upper trunk and erythema developed on day 10, coinciding with the onset of leucocyte recovery. The swelling and erythema resolved within 5 days, followed by desquamation. Chest x-rays and ECG revealed a large pericardial and right pleural effusion. These effusions resolved spontaneously by day 33 of the patient’s antineoplastic regimen. Author comment: ‘The appearance of erythema associated with lymphocyte recovery is due to immune hypersensitivity secondary to immaturity of the reconstituting immune system. Thus, we recommend that patients with acral erythema be examined for pleuropericarditis, especially if they experience chest pain.’ Vukelja SJ, et al. Pericarditis associated with acral erythema of chemotherapy: a syndrome of cutaneous and serosal toxicities? Cutis 52: 89-90, Aug 1993 - USA 800222154 1 Reactions 9 Oct 1993 No. 472 0114-9954/10/0472-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 472 - 9 Oct 1993
Antineoplastics
Pericarditis associated with acral erythema: casereport
A 19-year-old woman with Hodgkin’s disease in relapseexperienced acral erythema in association with anasymptomatic pericardial friction rub, following administrationof etoposide 60mg/kg and cyclophosphamide 100mg/kg, afterautologous bone marrow transplantation.
The patient had received preparative, fractionated total bodyirradiation. Five days after initiation of etoposide andcyclophosphamide, she experienced substernal pleuritic chestpain, which lasted for several days. Swelling of the palms,metacarpophalangeal and interphalangeal joints, amaculopapular eruption over the upper trunk and erythemadeveloped on day 10, coinciding with the onset of leucocyterecovery. The swelling and erythema resolved within 5 days,followed by desquamation.
Chest x-rays and ECG revealed a large pericardial and rightpleural effusion. These effusions resolved spontaneously byday 33 of the patient’s antineoplastic regimen.
Author comment: ‘The appearance of erythema associatedwith lymphocyte recovery is due to immune hypersensitivitysecondary to immaturity of the reconstituting immune system.Thus, we recommend that patients with acral erythema beexamined for pleuropericarditis, especially if they experiencechest pain.’Vukelja SJ, et al. Pericarditis associated with acral erythema of chemotherapy: asyndrome of cutaneous and serosal toxicities? Cutis 52: 89-90, Aug 1993 -USA 800222154
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Reactions 9 Oct 1993 No. 4720114-9954/10/0472-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
