Antineoplastics
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Reactions 1306 - 19 Jun 2010 Antineoplastics Eruptive lentiginosis: case report A 35-year-old woman developed eruptive lentiginosis after treatment with CHOP chemotherapy. The woman had been diagnosed with non-Hodgkin’s lymphoma, and received six 3-weekly cycles of CHOP (cyclophosphamide, doxorubicin, vincristine and oral prednisolone [dosages not stated]). Six weeks after stopping chemotherapy, she developed multiple asymptomatic brownish macules over photoprotected areas of all four limbs. Physical examination showed multiple, discrete, non-scaly, brownish, flat, stellate macules of uniform colour and approximately 1–3mm in size, distributed over her arms and legs. The mucosae, palms and soles were not affected. There were no systemic abnormalities. Histological evaluation showed an increased number of cells in the basal layer, strongly positive for S-100 and HMB-45. These cells did not encroach into the epidermis or dermis, and did not form nests, which was consistent with a diagnosis of eruptive lentigines. The woman was advised to take protective measures against exposure to ultraviolet light, and is receiving regular follow-ups to monitor progression of the lesions. Author comment: "As our patient was 35 years old and developed a large number of lentigines, without a history of such lesions and with a positive temporal correlation with cancer chemotherapy, we believe that the lentigines were secondary to immunosuppression associated with the chemotherapy." De D, et al. Generalized eruptive lentiginosis induced by chemotherapy Clinical and Experimental Dermatology 35: e113-e115, No. 4, Jun 2010. Available from: URL: http://dx.doi.org/10.1111/j.1365-2230.2009.03725.x - India 803019461 1 Reactions 19 Jun 2010 No. 1306 0114-9954/10/1306-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1306 - 19 Jun 2010
Antineoplastics
Eruptive lentiginosis: case reportA 35-year-old woman developed eruptive lentiginosis
after treatment with CHOP chemotherapy.The woman had been diagnosed with non-Hodgkin’s
lymphoma, and received six 3-weekly cycles of CHOP(cyclophosphamide, doxorubicin, vincristine and oralprednisolone [dosages not stated]). Six weeks afterstopping chemotherapy, she developed multipleasymptomatic brownish macules over photoprotectedareas of all four limbs. Physical examination showedmultiple, discrete, non-scaly, brownish, flat, stellatemacules of uniform colour and approximately 1–3mm insize, distributed over her arms and legs. The mucosae,palms and soles were not affected. There were no systemicabnormalities. Histological evaluation showed an increasednumber of cells in the basal layer, strongly positive forS-100 and HMB-45. These cells did not encroach into theepidermis or dermis, and did not form nests, which wasconsistent with a diagnosis of eruptive lentigines.
The woman was advised to take protective measuresagainst exposure to ultraviolet light, and is receiving regularfollow-ups to monitor progression of the lesions.
Author comment: "As our patient was 35 years old anddeveloped a large number of lentigines, without a history ofsuch lesions and with a positive temporal correlation withcancer chemotherapy, we believe that the lentigines weresecondary to immunosuppression associated with thechemotherapy."De D, et al. Generalized eruptive lentiginosis induced by chemotherapy Clinicaland Experimental Dermatology 35: e113-e115, No. 4, Jun 2010. Available from:URL: http://dx.doi.org/10.1111/j.1365-2230.2009.03725.x - India 803019461
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Reactions 19 Jun 2010 No. 13060114-9954/10/1306-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
