Antineoplastics
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Reactions 706 - 20 Jun 1998 S Antineoplastics Reye’s syndrome in a child: case report A 6-year-old boy, who had achieved remission from Burkitt’s lymphoma after he was treated with antineoplastics * [dosages not stated], developed Reye’s syndrome 1 year later. The child presented with febrile rhinopharyngitis and was treated with antibacterials and antipyretics. Three weeks later, he experienced abdominal pain and vomiting, and, the following day, he had a short seizure. He was hospitalised and an examination showed hepatomegaly and decreased consciousness. Laboratory tests revealed the following serum levels: AST 502 IU/L; ALT 320 IU/L; glucose 3.2 mmol/L; ammonia 130 µmol/L and lactic acid 4.6 mmol/L. His reactive C protein was 5 mg/L. A liver biopsy showed diffuse macro- and microvesicular steatosis without inflammatory infiltration. The boy was intubated and treated with glucose, IV clonazepam, ampicillin and aciclovir. His level of consciousness normalised by hospital day 3 and his liver function tests normalised 5 days later. Author comment: A possible link between chemotherapy and Reye’s Syndrome could be found through the multicentred study currently under way in France, which surveys cases of Reye’s Syndrome. * His antineoplastic regimen included prednisone, vincristine, cyclophosphamide, methotrexate, doxorubicin, etoposide and cytarabine. Dubern B, et al. Reye’s syndrome in a child having received chemotherapy. Archives de Pediatrie 5: 342-343, Mar 1998 [French; summarised from a translation] - France 807148681 » Editorial comment: A search of Adisbase and Medline revealed only 1 previous case report of a possible association between the use of antineoplastic therapy and the development of Reye’s syndrome in children. 1 Reactions 20 Jun 1998 No. 706 0114-9954/10/0706-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 706 - 20 Jun 1998
SAntineoplastics
Reye’s syndrome in a child: case reportA 6-year-old boy, who had achieved remission from
Burkitt’s lymphoma after he was treated with antineoplastics*
[dosages not stated], developed Reye’s syndrome 1 year later.The child presented with febrile rhinopharyngitis and was
treated with antibacterials and antipyretics. Three weeks later,he experienced abdominal pain and vomiting, and, thefollowing day, he had a short seizure. He was hospitalised andan examination showed hepatomegaly and decreasedconsciousness. Laboratory tests revealed the following serumlevels: AST 502 IU/L; ALT 320 IU/L; glucose 3.2 mmol/L;ammonia 130 µmol/L and lactic acid 4.6 mmol/L. His reactiveC protein was 5 mg/L. A liver biopsy showed diffuse macro-and microvesicular steatosis without inflammatory infiltration.
The boy was intubated and treated with glucose, IVclonazepam, ampicillin and aciclovir. His level ofconsciousness normalised by hospital day 3 and his liverfunction tests normalised 5 days later.
Author comment: A possible link between chemotherapyand Reye’s Syndrome could be found through the multicentredstudy currently under way in France, which surveys cases ofReye’s Syndrome.
* His antineoplastic regimen included prednisone, vincristine,cyclophosphamide, methotrexate, doxorubicin, etoposide andcytarabine.
Dubern B, et al. Reye’s syndrome in a child having received chemotherapy.Archives de Pediatrie 5: 342-343, Mar 1998 [French; summarised from atranslation] - France 807148681
» Editorial comment: A search of Adisbase and Medlinerevealed only 1 previous case report of a possible associationbetween the use of antineoplastic therapy and the developmentof Reye’s syndrome in children.
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Reactions 20 Jun 1998 No. 7060114-9954/10/0706-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
