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from our files

BENZODIAZEPINE BONANZA (contd)

FLUNITRAZEPAM (Roche)

Therapeutic use Polygraphic sleep recordings before and after the administration of

Ounitrazepam. Jovanovic lJJ. Journal of International Medical Research

5: 77(1977) Diazepam and Ounitrazepam as induction agents for cardiac surgical

operations. Clarke. R.SJ. et al. Acta Anaesthesiologica Scandinavica 21: 282 (1977)

Anaesthetic induction and maintenance with Ounitrazepam. Hare. S.A. South

African Medical Journal 52: 432 (1977) Premedication with Ounitrazepam in gastrointestinal endoscopy. Rubin. J. et

at. South African Medical Journal 52: 562 (1977) Flunitrazepam. an investigational hypnotic drug: sleep laboratory evaluations.

Bixler. E.O. et at. Journal of Clinical Pharmacology 17: 569 (1977) Flunitrazepam compared with Althesin as an induction agent in balanced

anaesthesia. Mattila. M.A.K. et al. British Journal of Anaesthesia 49: 1041 (1977)

Flunitrazepam (RohypnoJ) compared with nitrazepam (Mogadon) and

aprobarbital as evening premedication prior to anesthesia: a controlled

clinical trial. Freuchen. l. et al. Current Therapeutic Research 23: 90 (1978)

Comparison of diazepam and Ounitrazepam for sedation during local

anaesthesia for bronchoscopy. Komila. K. et al. British Journal of Anaesthesia SO: 281 (1978)

Comparative evaluation of hypnotic efficacy of Ounitrazepam in psychiatric

in-patients. Singer. K et at. Acta Psychiatrica Scandinavica 57: 382 (1978) Effects of diazepam and Ounitrazepam on the undesired post-operative side­

effects of ketamine anaesthesia. Knoche. E. et al. Der Anaesthesist 27: 302 ( 1978)

A controlled long-term study of Ounitrazepam. nitrazepam and placebo. with

special regard to withdrawal effect,. Hartelius. H. et aL Acta Psychiatrica

Scandinavica 58: I (1978)

Flunitrazepam for acute psychiatric cases, Jurgensen. J. Revista Brasileira de

Clinica Terapeutica 7: 497 (19781

Flunitrazepam combined with local anaesthesia in 1400 operations.

Heermann. J. Clinical Otolaryngology 3: 509 (J 978) General anaesthesia with intravenous Ounitrazepam. continuous ketamine

infusion and muscle relaxant: a preliminary report. Houlton. PJ.C et al.

South African Medical Journal 54: 1048 (1978) Induction of anaesthesia in patient, with coronary artery disease:

Ounitrazepam. diazepam. ketamine. fentanyL A haemodynamic study.

Tarnow. J. et aL Anaesthesist 28: 9 (J 979) The sedative and amnesic effects of Ounitrazepam during regional anaesthesia.

Tolksdorf. W. et at. Praktische Anasthesie Wiederbelebung und

Intensivtherapie 14: 59 (19791 Flunitrazepam with anterograde amnesia and reduction of blood pressure

before local anaesthesia without intubation in 3000 ENT operations.

Heermann. J. Laryngologie Rhinologie. Otologie vereinigt mit

MonaL,schrift fur Ohrenheilkunde 58: 162 (1979)

Comparison of Ounitrazepam and diazepam for oral premedication in older

children. Richardson. FJ. et al. British Journal of Anaesthesia 51: J I J

( 1979)

Comparison of Lm. pethidine. diazepam and !1unitrazepam a, premedicants in

children undergoing otolaryngological surgery. Lindgren. L. et at. British

Journal of Anaesthesia 51: 321 (1979) Comparison of diazepam and Ounitrazepam as adjuncts to general anaesthesia

in preveilting arousal foHowing surgical stimuli. Mattila. M,A.K. et aL

British Journal of Anaesthesia 51: 329 (1979) Insomnia in clinical psychiatry. Singer. L. et aL La NouveHe Presse Medicale

8: 2529(1979)

0156-2703/79/1124-0019 $00.50/0 ©ADIS Press

Study of Ounitrazepam in 41 cases of severe insomnia in patients hospitalised

in psychiatry. Horber. M. et al. La NouveHe Presse Medicale 8: 2535 (J 979)

Clinical trial of flunitrazepam in a hospital department of general psychiatry.

Besancon. G. et aL La NouveHe Presse Medicale 8: 2538 (1979) Clinical trial of Ounitrazepam in the hospital practice of psychiatry. Brunner.

H. et al. La NouveIle Presse Medicale 8: 2541 (1979) Insomnia in recently 'disintoxicated' alcoholics: treatment using Ounitrazepam.

Gisselman. A. La Nouvelle Presse Medicale 8: 2544 (1979) Four years experience of a hypno-inducer in psychiatry. 200 patienL<; treated

with Ounitrazepam. Hug. R. et at. La Nouvelle Presse Medicale 8: 2548 (1979)

Benzodiazepine receptors: temperature dependence of [3 H]-Ounitrazepam

binding. Speth. R.C et at. Life Sciences 24: 351 (1979) Action of Ounitrazepam on organic and functional sleep disturbances. Schohn.

D. et al. La Nouvelle Presse Medicale 8: 2550 (1979) Flunitrazepam in hospital psychiatry. Clement. J. La Nouvelle Presse

Medicale 8: 2554 (J 979) Double-blind trial of Ounitrazepam in insomnia. Collard, M. et at. La

Nouvelle Presse Medicale g: 2559 (1979) Controlled trials of 4 hypnotics and a placebo in 1313 patients. Wickstrom. E.

La Nouvelle Presse Medicale 8: 2561 (1979) Study of Ounitrazepam in orthopaedic surgery and traumatology. Leclert. A.

et al. La Nouvelle Presse Medicale 8: 2567 (1979) Study of a hypnotic agent in the elderly individual. Bille. J. La Nouvelle Presse

Medicale 8: 2569 (1979) Study of Ounitrazepam in psychiatric treatment. Salomon. Ch. La Nouvelle

Presse Medicale g: 2571 (1979) Insomnia at altitude. Efficacy of Ounitrazepam. Lasserre. E. La Nouvelle

Presse Medicale 8: 2577 (J 979)

Adverse reactions Sequelae after the intravenous injection of three benzodiazepines - diazepam.

lorazepam. and Ounitrazepam. Hegarty. J .E. et al. British Medical Journal

2: 1384(1977)

Local sequelae folIo wing the i.v. injection of three benzodiazepines. Hegarty.

J.E. et at. British Journal of Anaesthesia 50: 78 (1978) Psychiatric complications of Rohypnol abuse. Teo. S.H. et al. Singapore

Medical Journal 20: 270 (1979) Rebound insomnia. A potential hazard folIo wing withdrawal of certain

benzodiazepines. Kales. A. et at. Journal of the American Medical

Association 241: 1692 (1979)

MEDAZEPAM (Roche)

Medazepam and the driving ability of anxious patients. Moore. N.C

Psychopharmacology 52: 103 (1977)

Plasma concentrations of benzodiazepines. Bond. AJ. et al. British Journal of

Clinical Pharmacology 4: 51 (1977)

Actions of iontophoretic phenytoin and medazepam on hippocampal neurons.

Matthews. W.J). et at. Journal of Pharmacology and Experimental

Therapeutics 20 I: 613 (1977)

Serum medazepam. diazepam. and N-desmethyl-diazepam levels after single

and multiple oral doses of medazepam. Viukari. M. et al. Annals of

Clinical Research 9: 284 ( I 977)

The acute effect of diazepine derivatives on the higher nervous activity in man.

Hrbek. J. et al. Aggressologie 19: 189 (] 978)

Ethological analysis of the action exerted by medazepam and diazepam on the

zoosocial behaviour of isolated mice, Poshivalov. V.P. Farmakologiya I

Toksikologiya 41.263 (1978)

Plasma concentrations of medazepam and its metabolites after oral

administration. Hailey. D.M. et at. British Journal of Anaesthesia 51: 493 (1979)

INPHARMA 24 Nov 1979 19

Triazolam (Upjohn)

Pharmacology An evaluation of the cardiopulmonary safety and efficacy of triazolam.

l1urazepam. and placebo as oral hypnotic agents. Knapp. R. et al. Clinical Pharmacology and Therapeutics 21 : 107 (I 977)

Bioavailability and pharmacokinetics of orally administered triazolam in normal subjects. Metzler. e.M . et al. Clinical PharmaCOlogy and Therapeutics 21: 111(1977)

Effects of certain benzodiazepine derivatives on disorganization of thought as manifested in speech. Gottschalk. L.A . Current Therapeutic Research 21 : 192 (1977)

Disposition of triazolam. 8-chloro-6-(o-chlorophenyI)-I -methyl-4H-s-triazolo [4.3'<>] [I.4] benzodiazepine. in the dog. Eberts, F.S. Jr. Drug Metabolism and Disposition 5: 547 (I 977)

Effect of triazolam during a polygraphic and behavioral wakefulness test. Fernandez-Guardiola . A. et al. Me.dicina Revista Mexicana 58: 76 (1978)

Behavioral and EEG effects of triazolam in comparison with those of diazepam. Ueki . S. et al. Folia Pharmacologica Japonica 74: 597 (978)

Effects of triazolam on conditioned behavior in rats. Gomita, Y. et al. Folia Pharmacologica Japonica 74: 615 (I 978)

Elektroencephalographic assessment of dosage and sleep-profile in a hypnotic triazolothienodiazepine. Rubicki . S. EEG Zeitschrift fur Elektroenzephalographie 10: 95 (1979)

Disposition of "C-triazolam. a short-acting hypnotic. in man. Eberts. F .S. et al. Pharmacologist 21: 168 (1979)

Clinical use Determining optimum dose and acute tolerance of triazolam. Wang. R.I.H . et.

al. Journal oflnternational Medical Research 5: 184 (I 977) Etude a double insu comparant 0.2 5rng de triazolam et 5mg de nitrazepam

chez des operes. Bossier, D. ACTA Therapeutica 3: 257 (1977) Long-term efficacy and safety of triazolam and l1urazepam. Leibowitz, M. et

al. Clinical Pharmacology and Therapeutics 21: 109 (1977) Triazolam: an effective hypnotic in general practice. Chatwin. J.e. et al.

Current Therapeutics Research 21 : 207 (1977) Comparative effectiveness of nine hypnotic drugs: sleep laboratory studies.

Kales, A. et al. Journal of Clinical Pharmacology 17: 207 (1977) The effects of triazolam [.25rng]on the sleep of insomniac subjects. Roth. T. et

al. Drugs Under Experimental and Clinical Research I: 271 (1977) Comparison of triazolam, l1urazepam. and placebo as hypnotics in geriatric

patients with insomnia. Reeves_ R.L. Journal of Clinical Pharmacology 17: 319(1977)

Multi-clinic cross-over comparison of triazolam (Halcion) and placebo in the treatment of co-existing insomnia and anxiety in anxious out-patients. Fabre. L.F. Jr. et al. Diseases of the Nervous System 38: 48'7 (1977)

Multiclinic double-blind comparison .oftriazolam and l1urazepam for seven nights in outpatients with insomni·,i\fabre. L.F. Journal of Clinical Pharmacology 17: 402 (1977) •

Een vergelijkende studie tussen tween slaapmiddelen: triazolam en nitrazepam. Verguts. L. et al. Acta Therapeutica 4: 5 (1978)

Comparative efficacy of triazolam. Ilurazepam and placebo in out-patient insomniacs. Bowen. AJ. Journal ofInternational Medical Research 6: 337 (1978)

A clinical comparison of triazolam with placebo and with secobarbital in insomniac patients. Okawa. K.K. et al. Journal of International Medical Research 6: 343 (1978)

Evaluation of triazolam. Ilurazepam. and placebo as hypnotic agents in pre­surgical patients. Knapp, R.B. et al. Current Therapeutic Research 23: 230 (I978)

Comparison of triazolam .25mg and Ilurazepam 15mg in treating geriatric insonllliacs. Kay. K. CUiient Therapeutic Research 23 : J81 (1978)

Triazolam in insomnia: a standard controlled trial. Nair. N.P. V. et al. Current Therapeutic Research 23: 388 (1978)

Double-blind cross-over study by general practitioners comparing triazolam versus nitrazepam in insomniac outpatients. Puech. A.-J. et al. Therapie 33: 287 (1978)

Long-term hypnotic efficacy and safety of triazolam and nurazepam. Leibowitz . M. et al. Journal of Clinical Pharmacology 18: 302 (1978)

Preference study of the hypnotic efficacy of triazolam 0.125mg compared to placebo in geriatric patients with insomnia. Lipani. J .A. Current Therapeutic Research 24: 397 (1978)

Multi-clinic double-blind comparison oftriazolam (Halcion) and placebo administered for 14 consecutive nights in outpatients with insomnia. Fabre. LF. et a/. Journal of Clinical Psychiatry 39: 679 (1978)

Comparison of the hypnotic activity of triazolam and flurazepam. Nair. N.P.V. et a/. L-Union Medicale du Canada 108: 187 (1979)

Methodology for demonstrating sustained efficacy of hypnotics: a comparative study of triazolam and nurazepam. Sundaresan. P.R. et al. Clinical Pharmacology and Therapeutics 25 : 391 (1979)

Rebound insomnia. A potential hazard following withdrawal of certain benzodiazepines. Kales, A. et al. Journal of the American Medical Association 241: 1692 (1979)

Two more benzodiazepines. Drug and Therapeutics Bulletin 17: 65 (1979) Reactions to triazolam. van der Kroef. e. Lancet 2: 526 (1979) Behavioural reactions to triazolam. Macleod . N. et al. Lancet 2: 638 (1979)