Antineoplastics/radiotherapy
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Reactions 564 - 19 Aug 1995 Antineoplastics/radiotherapy Disseminated superficial actinic porokeratosis: case report Abrupt development of disseminated superficial actinic porokeratosis occurred in a 62-year-old man with high-grade lymphoma within days of receiving high-dose myeloablative antineoplastic therapy and total body irradiation. Myeloablative therapy was given in preparation for an autologous peripheral blood stem cell transplant, and consisted of cyclophosphamide 100 mg/kg and etoposide 60 mg/kg, and total body irradiation (1200 cGY). On day 10 after completion of this regimen, the man developed a widely disseminated, erythematous skin eruption on his trunk, arms and legs and a diagnosis of disseminated superficial actinic porokeratosis was made. The eruption resolved completely after 10 days and remained stable until the patient died of an extensive relapse of lymphoma approximately 2 months later. Author comment: The development of disseminated superficial actinic porokeratosis has previously been reported in association with antineoplastic therapy in malignancy, and immunosuppressive therapy for solid organ transplantation. However, this is the first report of such an abrupt onset of this cutaneous disorder within days of extremely aggressive immunosuppressive therapy. Fields LL, et al. Rapid development of disseminated superficial porokeratosis after transplant induction therapy. Bone Marrow Transplantation 15: 993-995, Jun 1995 - USA 800379416 1 Reactions 19 Aug 1995 No. 564 0114-9954/10/0564-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics/radiotherapy
Reactions 564 - 19 Aug 1995
Antineoplastics/radiotherapy
Disseminated superficial actinic porokeratosis: casereport
Abrupt development of disseminated superficial actinicporokeratosis occurred in a 62-year-old man with high-gradelymphoma within days of receiving high-dose myeloablativeantineoplastic therapy and total body irradiation.Myeloablative therapy was given in preparation for anautologous peripheral blood stem cell transplant, andconsisted of cyclophosphamide 100 mg/kg and etoposide 60mg/kg, and total body irradiation (1200 cGY).
On day 10 after completion of this regimen, the mandeveloped a widely disseminated, erythematous skin eruptionon his trunk, arms and legs and a diagnosis of disseminatedsuperficial actinic porokeratosis was made. The eruptionresolved completely after 10 days and remained stable untilthe patient died of an extensive relapse of lymphomaapproximately 2 months later.
Author comment: The development of disseminatedsuperficial actinic porokeratosis has previously been reported inassociation with antineoplastic therapy in malignancy, andimmunosuppressive therapy for solid organ transplantation.However, this is the first report of such an abrupt onset of thiscutaneous disorder within days of extremely aggressiveimmunosuppressive therapy.Fields LL, et al. Rapid development of disseminated superficial porokeratosis aftertransplant induction therapy. Bone Marrow Transplantation 15: 993-995, Jun 1995- USA 800379416
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Reactions 19 Aug 1995 No. 5640114-9954/10/0564-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
