Antineoplastics/radiotherapy
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Reactions 510 - 16 Jul 1994 S Antineoplastics/radiotherapy Chronic granulocytic leukaemia?: case report A 22-year-old woman was treated aggressively with antineoplastics, radiotherapy and autologous bone marrow transplantation for Hodgkin’s disease. 22 months later, she was diagnosed with Philadelphia positive chronic granulocytic leukaemia (CGL). The woman had received three 28-day courses of PVACE- BOP which included vincristine, etoposide, procarbazine, chlorambucil, doxorubicin, vinblastine, bleomycin and prednisolone. This was followed by mantle radiotherapy (30 cGy). Six months later she underwent an autologous bone marrow transplant following high-dose melphalan and etoposide conditioning. Over the course of her treatment she had received a cumulative etoposide dose of 3.7 g/m 2 . Complete clinical remission of Hodgkin’s disease was achieved. However, 22 months later CGL was detected during a routine follow-up. She was treated with hydroxycarbamide and remained well in chronic-phase CGL 1 year later. Author comment: ‘The development of CGL after treatment for Hodgkin’s disease may have been no more than coincidental . . . or may have been caused by or precipitated by the chemo/radiotherapy she received’. The possible association between etoposide and CGL in this case should also be noted. Jackson GH, et al. Rapid onset of chronic granulocytic leukaemia after treatment for Hodgkin’s disease. British Journal of Haematology 87: 193-195, May 1994 - England 800275388 1 Reactions 16 Jul 1994 No. 510 0114-9954/10/0510-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics/radiotherapy
Reactions 510 - 16 Jul 1994
SAntineoplastics/radiotherapy
Chronic granulocytic leukaemia?: case reportA 22-year-old woman was treated aggressively with
antineoplastics, radiotherapy and autologous bone marrowtransplantation for Hodgkin’s disease. 22 months later, shewas diagnosed with Philadelphia positive chronic granulocyticleukaemia (CGL).
The woman had received three 28-day courses of PVACE-BOP which included vincristine, etoposide, procarbazine,chlorambucil, doxorubicin, vinblastine, bleomycin andprednisolone. This was followed by mantle radiotherapy (30cGy). Six months later she underwent an autologous bonemarrow transplant following high-dose melphalan andetoposide conditioning. Over the course of her treatment shehad received a cumulative etoposide dose of 3.7 g/m2.
Complete clinical remission of Hodgkin’s disease wasachieved. However, 22 months later CGL was detected duringa routine follow-up. She was treated with hydroxycarbamideand remained well in chronic-phase CGL 1 year later.
Author comment: ‘The development of CGL after treatmentfor Hodgkin’s disease may have been no more thancoincidental . . . or may have been caused by or precipitated bythe chemo/radiotherapy she received’. The possible associationbetween etoposide and CGL in this case should also be noted.Jackson GH, et al. Rapid onset of chronic granulocytic leukaemia after treatmentfor Hodgkin’s disease. British Journal of Haematology 87: 193-195, May 1994 -England 800275388
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Reactions 16 Jul 1994 No. 5100114-9954/10/0510-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
