Antineoplastics
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Reactions 463 - 7 Aug 1993 Antineoplastics Neurological manifestations in children: incidence study An assessment of 55 children, 2-66 months after diagnosis of acute lymphoblastic leukaemia (ALL), showed lower IQ scores in: (1) female (n = 31) vs male patients (n = 31), (2) those aged < 5 years at diagnosis (26) vs those > 5 years and (3) those who had received radiotherapy (51) compared with those children who had not. All the patients had received CNS-directed therapy including intrathecal methotrexate [dosage and duration of therapy not given] and were 1.1-16.4 years old at diagnosis. Subsequent IQ tests showed mean score reductions of 2.9, 16.2 and 32.5 at mean intervals of 3.1, 5.9 and 7.2 years, respectively, after the first IQ test. Three of the 4 nonirradiated patients showed no IQ change. Follow-up duration ranged from 5.4 to 15.8 (mean 9.7) years. Precocious puberty was observed in 10/37 girls and 1/44 boys. Author comment: Children with ALL who are long-term survivors following CNS-directed antineoplastic therapy show similar effects to previous short-term findings. Notably, girls appear to be more vulnerable to CNS-directed therapy than boys, resulting in decreased IQ and precocious puberty. Kato M, et al. Ten-year survey of the intellectual deficits in children with acute lymphoblastic leukemia receiving chemoimmunotherapy. Medical and Pediatric Oncology 21: 435-440, No. 6, 1993 - Japan 800210748 1 Reactions 7 Aug 1993 No. 463 0114-9954/10/0463-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 463 - 7 Aug 1993
Antineoplastics
Neurological manifestations in children: incidencestudy
An assessment of 55 children, 2-66 months after diagnosisof acute lymphoblastic leukaemia (ALL), showed lower IQscores in: (1) female (n = 31) vs male patients (n = 31), (2)those aged < 5 years at diagnosis (26) vs those > 5 years and(3) those who had received radiotherapy (51) compared withthose children who had not.
All the patients had received CNS-directed therapy includingintrathecal methotrexate [dosage and duration of therapy notgiven] and were 1.1-16.4 years old at diagnosis.
Subsequent IQ tests showed mean score reductions of 2.9,16.2 and 32.5 at mean intervals of 3.1, 5.9 and 7.2 years,respectively, after the first IQ test. Three of the 4 nonirradiatedpatients showed no IQ change.
Follow-up duration ranged from 5.4 to 15.8 (mean 9.7)years. Precocious puberty was observed in 10/37 girls and1/44 boys.
Author comment: Children with ALL who are long-termsurvivors following CNS-directed antineoplastic therapy showsimilar effects to previous short-term findings. Notably, girlsappear to be more vulnerable to CNS-directed therapy thanboys, resulting in decreased IQ and precocious puberty.Kato M, et al. Ten-year survey of the intellectual deficits in children with acutelymphoblastic leukemia receiving chemoimmunotherapy. Medical and PediatricOncology 21: 435-440, No. 6, 1993 - Japan 800210748
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Reactions 7 Aug 1993 No. 4630114-9954/10/0463-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
